{"id":"W4302424796","doi":"10.1016/j.molcel.2022.09.007","title":"Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas","year":2022,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; McGill University; Princess Margaret Cancer Centre; McGill Genome Centre","funders":"National Institute of Dental and Craniofacial Research; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health","keywords":"Biology; Cancer research; DNA methylation; Chromatin; Immune system; Interferon; Epigenomics; Histone; Epigenetics; Innate immune system; Chromatin immunoprecipitation; Immunology; DNA; Gene expression; Genetics; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000122741,0.0001138831,0.0002040198,0.0001591541,0.0001523851,0.0003416367,0.0001807654,0.0002555499,0.001894467],"category_scores_gemma":[0.0001357326,0.0001199451,0.0001547761,0.000100092,0.0001979119,0.0001617769,0.0002113122,0.0005368924,0.00033539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003011749,"about_ca_system_score_gemma":0.0002153989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000528141,"about_ca_topic_score_gemma":0.0007836164,"domain_scores_codex":[0.9998877,0.00001487295,0.000007105721,0.0000175136,0.00003078195,0.00004198515],"domain_scores_gemma":[0.9999236,0.0000154421,0.00001364708,0.0000165637,0.000008553413,0.00002218312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001128749,0.00002427205,0.0006877808,0.0000107468,0.000004557343,0.00007811521,0.000007369189,0.00006915485,0.9972793,0.0002924373,0.00004357895,0.00138981],"study_design_scores_gemma":[0.00002046258,0.0003168434,0.01733605,0.000002775104,0.00001636263,0.0005130121,0.00008299334,0.001181931,0.9782273,0.0002948181,0.002003378,0.000004183103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996684,0.0005811088,0.0005818577,0.0001086937,0.00001687225,0.000009364616,0.00007379348,0.00003649598,0.001907843],"genre_scores_gemma":[0.9989086,0.000118887,0.00009310851,0.00002306941,0.000003922314,0.000002798888,0.00003252743,0.000003158236,0.0008139312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001894467,"threshold_uncertainty_score":0.006337643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007126746983249766,"score_gpt":0.2363900079826129,"score_spread":0.2292632609993631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}