{"id":"W4302424796","doi":"10.1016/j.molcel.2022.09.007","title":"Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas","year":2022,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; McGill University; Princess Margaret Cancer Centre; McGill Genome Centre","funders":"National Institute of Dental and Craniofacial Research; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health","keywords":"Biology; Cancer research; DNA methylation; Chromatin; Immune system; Interferon; Epigenomics; Histone; Epigenetics; Innate immune system; Chromatin immunoprecipitation; Immunology; DNA; Gene expression; Genetics; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003768596,0.0002030948,0.0001849036,0.000145344,0.000165444,0.00001948794,0.0002367441,0.00008686484,0.00007029721],"category_scores_gemma":[0.00003013178,0.0002408078,0.0001374386,0.0002067098,0.00004049149,0.00000415161,0.0002792492,0.0002077744,0.00001161855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008750604,"about_ca_system_score_gemma":0.00008918732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00013562,"about_ca_topic_score_gemma":0.00001154904,"domain_scores_codex":[0.9982723,0.0002908366,0.0003473504,0.0004959448,0.0002881112,0.0003054699],"domain_scores_gemma":[0.9992436,0.00001477875,0.0001538459,0.0004682627,0.00004729039,0.00007227658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005261982,0.000188296,0.001459448,0.00002196092,0.000003733551,0.00004392371,0.0001498668,0.006339999,0.9912006,0.00002245298,0.00004214396,0.0004749676],"study_design_scores_gemma":[0.001021555,0.0004170478,0.002319828,0.000001564877,0.0000186325,0.000003143553,0.0001358879,0.0005971062,0.9781134,0.0001818176,0.0169073,0.0002826957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762519,0.01419724,0.003140561,0.00006598047,0.0002670904,0.0003243441,0.00001821763,0.00001463412,0.005720025],"genre_scores_gemma":[0.9975345,0.00007952948,0.0007952019,0.0001410699,0.00004975605,0.00006751774,0.000465564,0.00004991773,0.0008169772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02128256,"threshold_uncertainty_score":0.9819855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007126746983249766,"score_gpt":0.2363900079826129,"score_spread":0.2292632609993631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}