{"id":"W4302762971","doi":"10.1111/imr.13144","title":"Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation","year":2022,"lang":"en","type":"review","venue":"Immunological Reviews","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Kidney Research UK; Medical Research Council; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"CLARITY; Complement (music); Complement system; Transplantation; Lectin pathway; Organ transplantation; Immunology; Alternative complement pathway; Classical complement pathway; Medicine; Reperfusion injury; Ischemia; Neuroscience; Biology; Immune system; Internal medicine; Phenotype; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007957598,0.0005518016,0.002237293,0.00008051549,0.0005049147,0.00004860373,0.0003546119,0.000267419,0.001536417],"category_scores_gemma":[0.0002829049,0.0003350344,0.0002510816,0.0001555613,0.0008648342,0.0000678587,0.0001508331,0.0003989574,0.000034241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008326297,"about_ca_system_score_gemma":0.0001668019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002756442,"about_ca_topic_score_gemma":0.000007385722,"domain_scores_codex":[0.9966737,0.0009893276,0.001092547,0.0007847312,0.00007243297,0.0003872521],"domain_scores_gemma":[0.9977334,0.001121378,0.0007086831,0.0003613837,0.0000390394,0.00003610978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001793935,0.00006874022,0.000004555063,0.01753139,0.0002044049,0.000006618901,0.00006659859,6.455961e-8,0.000139348,0.0001819776,0.0001860554,0.9814308],"study_design_scores_gemma":[0.0003666355,0.0006197848,0.000004588499,0.007720434,0.001329739,0.0003707801,0.0001328621,5.175048e-7,0.0001279568,0.00004684231,0.9888566,0.0004232788],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005590189,0.9940009,0.0002129485,0.00003789079,0.0001142167,0.004364225,0.0005861864,0.00006278142,0.00006184357],"genre_scores_gemma":[0.0003890112,0.993382,0.0002080333,0.0000563631,0.00001036247,0.00501006,0.0008472002,0.00002949237,0.00006742532],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9886705,"threshold_uncertainty_score":0.9999102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08762169956506756,"score_gpt":0.3624290992185627,"score_spread":0.2748073996534952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}