{"id":"W4302763178","doi":"10.2196/39785","title":"Biomarkers of Exposure and Potential Harm in Exclusive Users of Nicotine Pouches and Current, Former, and Never Smokers: Protocol for a Cross-sectional Clinical Study","year":2022,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Cotinine; Nicotine; Cross-sectional study; Physiology; Urinary system; Smokeless tobacco; Urine; Environmental health; Internal medicine; Pathology; Population; Tobacco use","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009382085,0.003627301,0.005080391,0.001834531,0.003795123,0.001303191,0.002083005,0.004136177,0.02228134],"category_scores_gemma":[0.008023561,0.001944541,0.002166638,0.00177739,0.00122751,0.001586593,0.001414563,0.003215107,0.007162392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002095798,"about_ca_system_score_gemma":0.006758474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003106692,"about_ca_topic_score_gemma":0.004512084,"domain_scores_codex":[0.9945121,0.002589727,0.0009661526,0.0007630523,0.0005372032,0.000631819],"domain_scores_gemma":[0.9938326,0.0008486746,0.0009317828,0.00082032,0.002649326,0.0009172922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4506759,0.1648415,0.1152904,0.01899064,0.002166049,0.002917747,0.003731247,0.008751567,0.02816693,0.006647061,0.07106416,0.1267567],"study_design_scores_gemma":[0.232021,0.2113132,0.3240834,0.005328712,0.001634831,0.001672684,0.003189795,0.009851896,0.01015425,0.006738051,0.1931828,0.0008295326],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01894783,0.0003748547,0.004207517,0.0002150108,0.0001713523,0.9706497,0.00357387,0.0001103402,0.001749504],"genre_scores_gemma":[0.009456301,0.0001604719,0.003766315,0.0002415702,0.0000467701,0.9844897,0.001071888,0.000008349132,0.0007587012],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02228134,"threshold_uncertainty_score":0.07453853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4069694029360026,"score_gpt":0.6198091234888153,"score_spread":0.2128397205528127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}