{"id":"W4302774629","doi":"10.1515/jcim-2022-0301","title":"A randomized, double-blind, placebo-controlled, cross-over trial to evaluate the effect of EstroSense <sup>®</sup> on 2-hydroxyestrone:16α-hydroxyestrone ratio in premenopausal women","year":2022,"lang":"en","type":"article","venue":"Journal of Complementary and Integrative Medicine","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Coquitlam College; CARE Canada; University of British Columbia","funders":"","keywords":"Placebo; Double blind; Medicine; Randomized controlled trial; Gynecology; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006438357,0.0003785065,0.00138063,0.0002574212,0.0002121083,0.00002188338,0.0003338706,0.00006827608,0.0003852804],"category_scores_gemma":[0.0004252904,0.0001890336,0.0002349634,0.0002160264,0.0003868298,0.0000185235,0.0001641348,0.000743432,0.000001102224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000129634,"about_ca_system_score_gemma":0.0001173922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007942359,"about_ca_topic_score_gemma":0.000008813494,"domain_scores_codex":[0.9952623,0.002065125,0.001334134,0.0002994678,0.0006851064,0.0003538619],"domain_scores_gemma":[0.998215,0.00068724,0.0005512779,0.0002507707,0.0001215096,0.000174155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9534966,0.000186763,0.0006985266,0.00001700269,0.0009075258,0.00002622373,0.001622711,0.006148526,0.03550597,0.0001180945,0.0009277003,0.0003443828],"study_design_scores_gemma":[0.9241303,0.0549113,0.00005878717,0.00009334295,0.0003290874,0.00008904534,0.001394806,0.001432125,0.01644699,0.00005018982,0.0008964878,0.0001675904],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939647,0.001020785,0.0001753608,0.000912525,0.0003145713,0.003298104,0.00002545572,0.00000296254,0.0002855639],"genre_scores_gemma":[0.998336,0.000100303,0.00004193183,0.0002998442,0.0005021532,0.0004244602,0.00005892408,0.0000215834,0.0002147938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05472453,"threshold_uncertainty_score":0.7708565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521179399449121,"score_gpt":0.3289504000072941,"score_spread":0.313738606012803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}