{"id":"W4302774629","doi":"10.1515/jcim-2022-0301","title":"A randomized, double-blind, placebo-controlled, cross-over trial to evaluate the effect of EstroSense <sup>®</sup> on 2-hydroxyestrone:16α-hydroxyestrone ratio in premenopausal women","year":2022,"lang":"en","type":"article","venue":"Journal of Complementary and Integrative Medicine","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Coquitlam College; CARE Canada; University of British Columbia","funders":"","keywords":"Placebo; Double blind; Medicine; Randomized controlled trial; Gynecology; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00187936,0.001421953,0.003855259,0.0005698508,0.00083531,0.0007449494,0.001035008,0.002541942,0.007189053],"category_scores_gemma":[0.002122182,0.001056965,0.001064452,0.000457506,0.00150137,0.0008816965,0.0004162379,0.001858863,0.0009517155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006646151,"about_ca_system_score_gemma":0.001856569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001970379,"about_ca_topic_score_gemma":0.003447167,"domain_scores_codex":[0.9991896,0.0003625282,0.00007249547,0.000191034,0.00007209751,0.000112326],"domain_scores_gemma":[0.9986526,0.0003930656,0.0002444766,0.0001247527,0.000149121,0.0004358304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9874853,0.006046378,0.0001467093,0.0002431662,0.0001719161,0.0000100156,0.00001686658,0.00003910139,0.002180429,0.00002501098,0.000131079,0.003504044],"study_design_scores_gemma":[0.9107662,0.08731402,0.0009857591,0.000016615,0.0001680128,0.000006982842,0.00001214561,0.0001044898,0.0003345449,0.00004189929,0.0002426239,0.00000677242],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834191,0.003418853,0.0006297245,0.0005062791,0.0009172912,0.008619069,0.0008749783,0.0001413199,0.001473335],"genre_scores_gemma":[0.9727119,0.002628761,0.002992158,0.001327739,0.0006841099,0.01300509,0.0008153706,0.00002621221,0.005808562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007189053,"threshold_uncertainty_score":0.02404982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521179399449121,"score_gpt":0.3289504000072941,"score_spread":0.313738606012803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}