{"id":"W4302790179","doi":"10.17615/h6h3-eh02","title":"A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University of North Carolina at Chapel Hill; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; NIH Office of the Director; Ontario Ministry of Health and Long-Term Care; Ontario Genomics Institute; National Institutes of Health; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Wellcome Trust; University of Toronto; Canadian Institutes of Health Research; National Science Foundation","keywords":"Methyltransferase; Chemistry; Cell biology; Biochemistry; Biology; Methylation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006855044,0.0001249815,0.0001355086,0.00002462393,0.00003892895,0.00006374608,0.00006899069,0.000134732,0.0000083103],"category_scores_gemma":[0.00007977333,0.0001214356,0.0000326196,0.0001389305,0.00009516572,0.00001458343,0.00007484524,0.0001103347,0.000001974396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004431125,"about_ca_system_score_gemma":0.00009117284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001443484,"about_ca_topic_score_gemma":0.00001028913,"domain_scores_codex":[0.9992653,0.00006058701,0.0001201255,0.0003174603,0.00007795494,0.0001585476],"domain_scores_gemma":[0.999738,0.00002354961,0.00002764148,0.00008985752,0.00002249757,0.00009844175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001398098,0.00003661927,0.002310167,0.00002985192,0.00001326385,0.000001747936,0.0004138593,0.00001039217,0.9943665,0.0008584014,0.00005925228,0.001760121],"study_design_scores_gemma":[0.0004265693,0.0001374477,0.00118298,0.000005501769,0.000006983053,3.980535e-7,0.00002404408,0.000101475,0.9933147,0.002393334,0.002261146,0.0001454207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912231,0.001082838,0.006257763,0.0008006958,0.00002205084,0.0001737499,0.00001426702,0.00001539825,0.0004101107],"genre_scores_gemma":[0.9938703,0.00005393282,0.005609423,0.0002708109,0.0001019199,0.00001256542,0.00002576958,0.00001626614,0.0000389967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002647189,"threshold_uncertainty_score":0.4952002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138958981727635,"score_gpt":0.2156194995891961,"score_spread":0.2017236014164326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}