{"id":"W4302792126","doi":"10.26443/msurj.v5i1.68","title":"ERK-CREB Signaling Dysregulation with Increasing Levels of The β-amyloid Protein","year":2010,"lang":"en","type":"article","venue":"McGill Science Undergraduate Research Journal","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"CREB; MAPK/ERK pathway; Phosphorylation; Molecular biology; Protein kinase A; Biology; Cell biology; Cell culture; Chemistry; Biochemistry; Transcription factor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.006357613,0.0001668168,0.0002313155,0.0005963154,0.002637722,0.0001966897,0.0005955201,0.00006144044,0.00008852586],"category_scores_gemma":[0.0014008,0.00008972221,0.0001120944,0.002287097,0.002506769,0.0006005083,0.0002224682,0.001448005,0.00001847344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074792,"about_ca_system_score_gemma":0.002322664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001756391,"about_ca_topic_score_gemma":0.00006044711,"domain_scores_codex":[0.9934744,0.0004318302,0.0003402606,0.0003730064,0.00436186,0.001018691],"domain_scores_gemma":[0.9963042,0.0002103679,0.000183164,0.0005062213,0.001912549,0.0008835694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006885567,0.0004587519,0.02119725,0.00005243885,0.0005370671,0.0001632037,0.0000588219,0.00004879987,0.9616375,0.005709983,0.00002634129,0.009421265],"study_design_scores_gemma":[0.004195998,0.001631997,0.1794686,0.001211246,0.0001679747,0.002795986,0.0004074977,0.001553105,0.7811059,0.02678437,0.0003491658,0.0003281289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899277,0.0001015223,0.00006048839,0.006286282,0.00006088698,0.0008104927,0.0000155513,0.00001726063,0.002719815],"genre_scores_gemma":[0.9972004,0.00001668491,0.002486338,0.00002297598,0.0001091185,0.00001478645,0.000001078507,0.00002214081,0.0001264241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1805316,"threshold_uncertainty_score":0.9986607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06679825371343398,"score_gpt":0.3683107917553119,"score_spread":0.3015125380418779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}