{"id":"W4303183085","doi":"10.3389/fendo.2022.932516","title":"Alpha cell dysfunction in type 1 diabetes is independent of a senescence program","year":2022,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Children's Hospital Research Institute of Manitoba; University of Manitoba; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Senescence; Islet; Biology; NOD mice; Cell biology; Endocrinology; Phenotype; Internal medicine; Nod; Insulin; Immunology; Diabetes mellitus; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011299,0.0001114811,0.00037105,0.0004572937,0.00003043089,0.000002528805,0.00009116378,0.000053251,0.0004012173],"category_scores_gemma":[0.00006949794,0.000114904,0.00004930307,0.000541538,0.00008336874,0.00003497382,0.00008786512,0.000318372,0.00000794629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000179168,"about_ca_system_score_gemma":0.00009637108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000586968,"about_ca_topic_score_gemma":0.000003411624,"domain_scores_codex":[0.9987794,0.0001019361,0.0002915039,0.0002671898,0.0001910769,0.0003688684],"domain_scores_gemma":[0.9995782,0.00003193381,0.00008496486,0.0002198173,0.00003713169,0.00004795402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002754793,0.0005259247,0.9680221,0.00007856211,0.00002868275,0.00004700144,0.0002966704,0.00004412737,0.003892779,0.00002958212,0.009038507,0.01772058],"study_design_scores_gemma":[0.01176306,0.004825781,0.8336655,0.00008100051,0.0001380365,0.00006173408,0.005626765,0.005990742,0.0636447,0.0007733687,0.0729888,0.0004405083],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922444,0.001901457,0.00006204058,0.0003650717,0.00164206,0.0004455764,0.000005861681,0.00004817497,0.003285323],"genre_scores_gemma":[0.9960382,0.000131817,0.002149781,0.0005123024,0.00002718197,0.0001740137,0.00002166194,0.00001291886,0.0009321178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1343566,"threshold_uncertainty_score":0.468565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125559018510962,"score_gpt":0.245557408167265,"score_spread":0.2343018179821554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}