{"id":"W4303183085","doi":"10.3389/fendo.2022.932516","title":"Alpha cell dysfunction in type 1 diabetes is independent of a senescence program","year":2022,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Children's Hospital Research Institute of Manitoba; University of Manitoba; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Senescence; Islet; Biology; NOD mice; Cell biology; Endocrinology; Phenotype; Internal medicine; Nod; Insulin; Immunology; Diabetes mellitus; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004347894,0.0004847381,0.0003816796,0.0003812054,0.0002034376,0.0005504965,0.0001767735,0.0003332089,0.00150315],"category_scores_gemma":[0.0003164119,0.0001243812,0.0003867237,0.0002603822,0.0003655623,0.0003398601,0.0002966201,0.0006739024,0.0005242976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001552751,"about_ca_system_score_gemma":0.000179616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001467396,"about_ca_topic_score_gemma":0.000165737,"domain_scores_codex":[0.9998342,0.00003484022,0.00001975764,0.00004632553,0.00003736559,0.00002754191],"domain_scores_gemma":[0.9996481,0.00004686967,0.0001272834,0.0000504888,0.00003646855,0.00009082085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002213531,0.0001647935,0.01990524,0.0003302472,0.00004034985,0.0007224533,0.0001345965,0.00008146207,0.9573385,0.0005119533,0.0001995255,0.01835727],"study_design_scores_gemma":[0.000158005,0.005217575,0.5004162,0.0002211229,0.0002519512,0.01021504,0.0004972154,0.0009429228,0.4613628,0.001994089,0.01867735,0.00004574688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983676,0.0109074,0.002080825,0.0001776846,0.00009485954,0.00002233119,0.0002846181,0.00007535712,0.002680871],"genre_scores_gemma":[0.991973,0.004805787,0.001005441,0.0001131693,0.0000748275,0.00002376098,0.0003170864,0.00001436873,0.001672469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00150315,"threshold_uncertainty_score":0.005028486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125559018510962,"score_gpt":0.245557408167265,"score_spread":0.2343018179821554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}