{"id":"W4303446442","doi":"10.1101/2022.10.03.509766","title":"Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institutes of Health; Parker Institute for Cancer Immunotherapy; University of Pennsylvania","keywords":"Effector; CD8; Cytotoxic T cell; Biology; Ex vivo; T cell; Cell biology; Epigenetics; Cancer research; Immune system; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009481449,0.0002251635,0.0001472942,0.00008834428,0.00007865353,0.000245697,0.0001150846,0.0001504735,0.001715605],"category_scores_gemma":[0.00006401182,0.00006692291,0.0001536862,0.00006295682,0.0001498055,0.0001361418,0.0001654316,0.0006045984,0.0003033584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001558561,"about_ca_system_score_gemma":0.0001330128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001488562,"about_ca_topic_score_gemma":0.0003744994,"domain_scores_codex":[0.9998847,0.00001420157,0.00001059029,0.00002648152,0.00002006461,0.00004397694],"domain_scores_gemma":[0.999947,0.000007873558,0.00001228841,0.000005927865,0.000004751147,0.00002225526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002975221,0.0000467358,0.0003575191,0.00003723527,0.000004246471,0.00002772667,0.00001257986,0.0001311125,0.9970875,0.0001015464,0.00006452529,0.001831627],"study_design_scores_gemma":[0.00003855636,0.001076368,0.003568853,0.000008913843,0.00001973873,0.0001053662,0.00004323662,0.001696899,0.9908277,0.00008901105,0.002520733,0.000004688716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963235,0.0005802384,0.001570022,0.00005339845,0.00003353239,0.00002020628,0.0002267255,0.00008214256,0.001110238],"genre_scores_gemma":[0.9981619,0.0001113583,0.0004864953,0.00004371579,0.000005952885,0.00001693285,0.0001385192,0.000007323982,0.001027893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715605,"threshold_uncertainty_score":0.005739272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501151024700386,"score_gpt":0.2642740642277319,"score_spread":0.2492625539807281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}