{"id":"W4303457093","doi":"10.1200/jco.22.01273","title":"Progression-Free Survival and Patterns of Response in Patients With Relapsed High-Risk Neuroblastoma Treated With Irinotecan/Temozolomide/Dinutuximab/Granulocyte-Macrophage Colony-Stimulating Factor","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Internal medicine; Chemoimmunotherapy; Irinotecan; Temozolomide; Progressive disease; Neuroblastoma; Granulocyte colony-stimulating factor; Oncology; Progression-free survival; Gastroenterology; Surgery; Cancer; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003147481,0.0001410059,0.0002578562,0.0003175875,0.00022908,0.0002832029,0.0002011106,0.0002746898,0.0007224752],"category_scores_gemma":[0.0008974813,0.0001034509,0.0002387991,0.0002484306,0.0002137624,0.0002565342,0.0001742025,0.0003312543,0.0001373892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00037404,"about_ca_system_score_gemma":0.0002181222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120102,"about_ca_topic_score_gemma":0.001849002,"domain_scores_codex":[0.9998356,0.00003546579,0.00001709489,0.00004804612,0.00003094989,0.00003285707],"domain_scores_gemma":[0.9995475,0.00008752763,0.0001964176,0.00001911983,0.00002423997,0.0001252624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001222536,0.00008164357,0.9922497,0.00001453004,0.00004798361,0.0003909735,0.0000770374,0.0001898632,0.001206288,0.0000137333,0.0001224156,0.004383341],"study_design_scores_gemma":[0.00007095403,0.001000119,0.995618,0.000009146323,0.00004040087,0.002084422,0.00009287943,0.000432376,0.0003306812,0.00002457582,0.0002908433,0.000005612565],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995149,0.0002219048,0.00002018978,0.00002080518,0.000002200517,0.000003420588,0.00006851153,0.000002331996,0.0001458314],"genre_scores_gemma":[0.9997244,0.00004724836,0.00002137429,0.00001678041,0.000003647759,0.000003467172,0.0001311123,6.565818e-7,0.00005106793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120102,"threshold_uncertainty_score":0.002713799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03646536451102339,"score_gpt":0.3768109796344001,"score_spread":0.3403456151233767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}