{"id":"W4303473149","doi":"10.1016/s1474-4422(22)00184-3","title":"Ageing and multiple sclerosis","year":2022,"lang":"en","type":"review","venue":"The Lancet Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":238,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Medical Research Council; Fondazione per la Ricerca Biomedica; Ohio State University; National Institutes of Health; Multiple Sclerosis Society; Fondazione Cariplo; National Eye Institute; Wellcome Trust; Conrad N. Hilton Foundation","keywords":"Multiple sclerosis; Remyelination; Ageing; Medicine; Disease; Neuroprotection; Immune system; Neuroscience; Central nervous system; Immunology; Psychology; Pathology; Myelin; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000634886,0.0003113224,0.002144225,0.0001365441,0.0003267819,0.0000221798,0.0003821525,0.0001411749,0.0003078632],"category_scores_gemma":[0.001213928,0.0001841983,0.0002399536,0.0002646278,0.0003316482,0.00001988567,0.001008802,0.001615419,0.00004974634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003196521,"about_ca_system_score_gemma":0.00007625034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000515171,"about_ca_topic_score_gemma":0.00001976789,"domain_scores_codex":[0.9975418,0.0007598249,0.0003354049,0.0004988525,0.0002936312,0.0005704591],"domain_scores_gemma":[0.996581,0.002365646,0.0001625077,0.000775998,0.00001956038,0.00009528115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008584603,0.0000284079,0.0001628611,0.004367231,0.0002159525,0.0001193173,0.00006132138,4.456219e-7,0.000009219438,0.00001562585,0.006114333,0.9888194],"study_design_scores_gemma":[0.0006704528,0.00024198,0.002906676,0.0005380152,0.0003514903,0.0002097252,0.000006009175,0.00002228032,3.25271e-7,0.000008281118,0.9949176,0.000127116],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005898142,0.9939874,4.619238e-7,0.002735743,0.0002295182,0.001076923,0.00005446387,0.00009397342,0.001231672],"genre_scores_gemma":[0.0002482687,0.9966069,0.00002373487,0.001787453,0.000784865,0.0002788325,0.00003651181,0.00006392252,0.0001694964],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9888033,"threshold_uncertainty_score":0.751139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3495520240052712,"score_gpt":0.3891217182035496,"score_spread":0.03956969419827844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}