{"id":"W4303473194","doi":"10.1016/s2352-3026(22)00284-8","title":"Health-related quality of life in patients given ciltacabtagene autoleucel for relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b–2, open-label study","year":2022,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Janssen Research and Development","keywords":"Medicine; Internal medicine; Multiple myeloma; Quality of life (healthcare); Refractory (planetary science); Clinical trial; Cancer; Chimeric antigen receptor; Oncology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004040117,0.0002324723,0.002377057,0.0002054634,0.0002809961,0.00001404759,0.0008973071,0.0001074832,0.0009167936],"category_scores_gemma":[0.001475876,0.0001714916,0.00008639788,0.0005957645,0.0001760076,0.00007278468,0.0007010577,0.0007616857,0.00001160751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003232102,"about_ca_system_score_gemma":0.0006982427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001902798,"about_ca_topic_score_gemma":0.001448143,"domain_scores_codex":[0.994648,0.002147683,0.001381722,0.00053289,0.0005899052,0.0006998343],"domain_scores_gemma":[0.996647,0.001223971,0.0006379369,0.00113864,0.0001760975,0.0001763306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2542171,0.09920891,0.5478284,0.001927541,0.001502647,0.0004288694,0.0245135,0.00006556751,0.01205634,0.0008441198,0.03089596,0.02651105],"study_design_scores_gemma":[0.6564474,0.04339799,0.2684587,0.0001780154,0.0001677802,0.0001578611,0.005820594,0.002946523,0.0006801172,0.000592676,0.02041736,0.0007350123],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855034,0.0003956389,0.00001861301,0.006620649,0.0002568325,0.006700232,0.0002164518,0.00006325227,0.0002248939],"genre_scores_gemma":[0.9956942,0.00003194056,0.000270006,0.001253539,0.00004727379,0.001179267,0.0001535984,0.00005607378,0.001314106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4022303,"threshold_uncertainty_score":0.9999965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1986124578034017,"score_gpt":0.447965213090437,"score_spread":0.2493527552870353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}