{"id":"W4303473194","doi":"10.1016/s2352-3026(22)00284-8","title":"Health-related quality of life in patients given ciltacabtagene autoleucel for relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b–2, open-label study","year":2022,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Janssen Research and Development","keywords":"Medicine; Internal medicine; Multiple myeloma; Quality of life (healthcare); Refractory (planetary science); Clinical trial; Cancer; Chimeric antigen receptor; Oncology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001355508,0.00124303,0.001925508,0.0003106348,0.0003835127,0.0008513023,0.0006341904,0.001327747,0.002656318],"category_scores_gemma":[0.0006639669,0.0004302744,0.001919977,0.0004008546,0.0009386431,0.0008419721,0.000382726,0.002809725,0.0005135752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006982856,"about_ca_system_score_gemma":0.00063319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007332192,"about_ca_topic_score_gemma":0.001315873,"domain_scores_codex":[0.9995512,0.000206136,0.00001963246,0.00007725508,0.00004421358,0.0001014887],"domain_scores_gemma":[0.9993219,0.000140573,0.0001699084,0.00006071936,0.00003752113,0.0002694039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8983737,0.03494824,0.01204561,0.0005827651,0.001782176,0.0001043388,0.0001401269,0.0007261273,0.01079604,0.00008048238,0.001179119,0.0392413],"study_design_scores_gemma":[0.5009291,0.445382,0.04908088,0.0000408478,0.001107442,0.000113116,0.00006731358,0.0007982707,0.001223837,0.0001119997,0.001100408,0.00004496298],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997773,0.0009363822,0.0001010124,0.0001396583,0.00005680249,0.0002915126,0.0003377144,0.00001642976,0.0003472969],"genre_scores_gemma":[0.9955648,0.000704154,0.0003666515,0.0005602906,0.0001853945,0.0007020448,0.001043271,0.000007238747,0.0008661121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002656318,"threshold_uncertainty_score":0.008886218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1986124578034017,"score_gpt":0.447965213090437,"score_spread":0.2493527552870353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}