{"id":"W4303512960","doi":"10.1039/d2ob01372j","title":"Efficient formation of hemoglobin bis-tetramers <i>via</i> selective acetylation of α-subunit amino groups by methyl acetyl phosphate","year":2022,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Acetylation; Protein subunit; Phosphate; Hemoglobin; Stereochemistry; Medicinal chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002741073,0.0002660763,0.0002844332,0.0000483112,0.0001453666,0.00001026901,0.0002962112,0.0002053152,0.0001789629],"category_scores_gemma":[0.00006451393,0.0002978172,0.0001855423,0.000623355,0.0001184804,0.00000730226,0.0002162838,0.0002055885,0.000002111312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001244514,"about_ca_system_score_gemma":0.0001376907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002180698,"about_ca_topic_score_gemma":9.530856e-7,"domain_scores_codex":[0.998245,0.0000948712,0.0004784746,0.0004480031,0.0004255465,0.0003080929],"domain_scores_gemma":[0.9988197,0.00001288803,0.00043009,0.0004632781,0.0001821319,0.00009192865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001516841,0.0001467065,0.00007959406,0.0001217362,0.00009984873,0.00000203005,0.0001309375,0.0001181418,0.9968735,0.000004184919,0.001243157,0.001028493],"study_design_scores_gemma":[0.0009114128,0.0002884803,0.00003425928,0.000009386977,0.00008226519,0.00006480992,0.0003574787,0.0004881112,0.9938809,0.00001775541,0.003591872,0.0002732291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8653179,0.001275235,0.1318684,0.00005953339,0.000134766,0.000279929,0.0001670759,0.00002601674,0.0008711274],"genre_scores_gemma":[0.9980081,0.00004594886,0.0003065264,0.0001136477,0.00004756895,0.00002777547,0.001220218,0.00004420287,0.0001860022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1326902,"threshold_uncertainty_score":0.9999474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003132968634058981,"score_gpt":0.1957469945102237,"score_spread":0.1926140258761647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}