{"id":"W4303575243","doi":"10.1101/2022.10.06.511062","title":"HIV-1 neutralization tiers are not relevant for inhibitors targeting the pre-hairpin intermediate","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Science Foundation","keywords":"Neutralization; Epitope; Virology; Human immunodeficiency virus (HIV); Antibody; HIV vaccine; Biology; Potency; Chemistry; Immunology; Virus; In vitro; Genetics; Vaccine trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003302103,0.0003417865,0.0003917369,0.0001960166,0.000137415,0.0007291012,0.000235726,0.0003165618,0.001399834],"category_scores_gemma":[0.0005135731,0.0001284158,0.0002820155,0.0001398538,0.0002682983,0.0002946502,0.0002200465,0.0008117688,0.0004297941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003715731,"about_ca_system_score_gemma":0.0002332913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005269633,"about_ca_topic_score_gemma":0.0005396082,"domain_scores_codex":[0.9995958,0.00006598826,0.00004259978,0.00006461881,0.0001378293,0.00009321379],"domain_scores_gemma":[0.9996465,0.00008964447,0.0001154377,0.0000439316,0.00004474956,0.00005964324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000412082,0.00007447385,0.004196231,0.00006633469,0.00003625766,0.0000563951,0.00001364125,0.0003492662,0.9901191,0.0004323676,0.0002229491,0.004020959],"study_design_scores_gemma":[0.00002986946,0.0007424127,0.03248552,0.000009232534,0.00004924213,0.0009420554,0.0000321389,0.002348492,0.9598126,0.0004553395,0.003080451,0.00001260475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847347,0.002776459,0.005238207,0.0001413482,0.00007356866,0.00008002834,0.0008104068,0.000176462,0.005968736],"genre_scores_gemma":[0.9973059,0.0002185957,0.00109971,0.0001134163,0.00000973962,0.00001234238,0.0005310795,0.00001267086,0.0006965832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399834,"threshold_uncertainty_score":0.004682958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358304020439531,"score_gpt":0.2381492442911997,"score_spread":0.2245662040868044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}