{"id":"W4303575247","doi":"10.1016/j.omto.2022.10.003","title":"Enhanced genomic stability of new miRNA-regulated oncolytic coxsackievirus B3","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Mitacs; Michael Smith Health Research BC; Canadian Cancer Society; University of British Columbia; Canadian Lung Association; British Columbia Lung Association","keywords":"Oncolytic virus; microRNA; Biology; Coding region; Genome; Virology; Reversion; Untranslated region; CRISPR; Virus; Coxsackievirus; Cancer research; Viral replication; Gene; Molecular biology; Computational biology; Genetics; Enterovirus; RNA; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007903805,0.0004135124,0.0005147031,0.0001443283,0.000228584,0.00003449728,0.0009988406,0.0001984421,0.001040749],"category_scores_gemma":[0.00007553679,0.0004536606,0.0003802166,0.0005347864,0.0002176867,0.000006577277,0.0004396325,0.0003978664,0.00002873502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117497,"about_ca_system_score_gemma":0.001314916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001036264,"about_ca_topic_score_gemma":0.00009529415,"domain_scores_codex":[0.9965435,0.0005495725,0.0006635972,0.0007897454,0.0007850266,0.0006686181],"domain_scores_gemma":[0.9976872,0.00003989341,0.0003072144,0.001475279,0.0002053748,0.0002850202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005660484,0.0004762106,0.000140161,0.00002188981,0.0003142584,0.00001600822,0.0002427133,0.002004795,0.9659945,0.00003533799,0.0004305867,0.02466303],"study_design_scores_gemma":[0.003681733,0.007583559,0.0003517317,0.000008393421,0.00003007873,0.00001407271,0.0001022933,0.0003279404,0.9717003,0.0003032469,0.01543511,0.0004615665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911922,0.004478966,0.001342407,0.0004094992,0.0002016255,0.001125318,0.00007536385,0.00003467572,0.001139928],"genre_scores_gemma":[0.9960662,0.0006239408,0.0004644598,0.0008566508,0.0001357174,0.0001155794,0.0001697578,0.0001333822,0.001434291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02420147,"threshold_uncertainty_score":0.9998724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02788435893359085,"score_gpt":0.3055836768484276,"score_spread":0.2776993179148368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}