{"id":"W4303575247","doi":"10.1016/j.omto.2022.10.003","title":"Enhanced genomic stability of new miRNA-regulated oncolytic coxsackievirus B3","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Mitacs; Michael Smith Health Research BC; Canadian Cancer Society; University of British Columbia; Canadian Lung Association; British Columbia Lung Association","keywords":"Oncolytic virus; microRNA; Biology; Coding region; Genome; Virology; Reversion; Untranslated region; CRISPR; Virus; Coxsackievirus; Cancer research; Viral replication; Gene; Molecular biology; Computational biology; Genetics; Enterovirus; RNA; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000215447,0.0002609394,0.0002023576,0.0002122942,0.0001670002,0.0004495866,0.0002038808,0.0002861453,0.0005236816],"category_scores_gemma":[0.0002376638,0.0001486113,0.0002451903,0.0001612085,0.0001687914,0.0001786601,0.0001731296,0.0005830164,0.0002263657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003621275,"about_ca_system_score_gemma":0.0001790486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008992463,"about_ca_topic_score_gemma":0.0007968788,"domain_scores_codex":[0.9998763,0.0000141299,0.00001221748,0.00003158416,0.00004461197,0.00002114291],"domain_scores_gemma":[0.9998767,0.00001864954,0.00004358134,0.00001502358,0.00001938783,0.00002652018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003856443,0.00000809541,0.00007602408,0.00001081491,0.000003155323,0.00001231374,0.000009795979,0.00006956755,0.9991177,0.00007454702,0.00001538767,0.0005641074],"study_design_scores_gemma":[0.000008887227,0.0001562394,0.001102543,0.000003032234,0.00001298951,0.0001393646,0.000008894646,0.001104453,0.9950932,0.00003200902,0.002332099,0.000006239994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991836,0.0009374116,0.005941063,0.00004780774,0.00003083402,0.00002638661,0.0003703017,0.000105402,0.0007048122],"genre_scores_gemma":[0.9903623,0.000447687,0.006580698,0.00003118869,0.000006434875,0.00003092173,0.001053426,0.00006948253,0.00141784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008992463,"threshold_uncertainty_score":0.002627432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02788435893359085,"score_gpt":0.3055836768484276,"score_spread":0.2776993179148368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}