{"id":"W4303579376","doi":"10.1111/all.15543","title":"Dual activation of estrogen receptor alpha and glucocorticoid receptor upregulate CRTh2‐mediated type 2 inflammation; mechanism driving asthma severity in women?","year":2022,"lang":"en","type":"article","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Western University","funders":"Canadian Institutes of Health Research; Western University; Canadian Allergy, Asthma and Immunology Foundation","keywords":"Asthma; Medicine; Immunology; Glucocorticoid receptor; Flow cytometry; Inflammation; Glucocorticoid; Downregulation and upregulation; Apoptosis; Annexin; Estrogen; Internal medicine; Endocrinology; Receptor; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781525,0.0001954276,0.0004044925,0.000194647,0.0001290433,0.0003097638,0.0001546113,0.0002221025,0.002771125],"category_scores_gemma":[0.0003028651,0.0001592116,0.0002460737,0.0001913479,0.0001880981,0.0001464855,0.0001981953,0.0002278779,0.0006052664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000148012,"about_ca_system_score_gemma":0.0001443705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004475295,"about_ca_topic_score_gemma":0.0004681147,"domain_scores_codex":[0.9998684,0.00003542655,0.00000587236,0.00003333378,0.00001841778,0.00003846569],"domain_scores_gemma":[0.9998804,0.00001921948,0.00004203437,0.00001406108,0.0000124849,0.00003165289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005641589,0.0002260518,0.4048476,0.0005343214,0.0002916883,0.002439543,0.0005606012,0.0001105554,0.5406336,0.0006665534,0.001897558,0.0421504],"study_design_scores_gemma":[0.0001040832,0.001093122,0.9641687,0.00005737449,0.000192286,0.003173128,0.0006125154,0.0003254755,0.02536807,0.0004590465,0.004430011,0.00001618226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819819,0.01432188,0.0007388409,0.0005195357,0.00009063944,0.00002319968,0.0005515049,0.00003236478,0.001740136],"genre_scores_gemma":[0.9955494,0.002272393,0.0002208802,0.0001887819,0.00007541449,0.00001898219,0.0001425364,0.000006385332,0.001525217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002771125,"threshold_uncertainty_score":0.00927037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007191580501633762,"score_gpt":0.2248028856979684,"score_spread":0.2176113051963346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}