{"id":"W4303579376","doi":"10.1111/all.15543","title":"Dual activation of estrogen receptor alpha and glucocorticoid receptor upregulate CRTh2‐mediated type 2 inflammation; mechanism driving asthma severity in women?","year":2022,"lang":"en","type":"article","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Western University","funders":"Canadian Institutes of Health Research; Western University; Canadian Allergy, Asthma and Immunology Foundation","keywords":"Asthma; Medicine; Immunology; Glucocorticoid receptor; Flow cytometry; Inflammation; Glucocorticoid; Downregulation and upregulation; Apoptosis; Annexin; Estrogen; Internal medicine; Endocrinology; Receptor; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001881257,0.0001359984,0.0002643066,0.000153953,0.00008270949,0.000008262809,0.00005939187,0.00006717614,0.001331438],"category_scores_gemma":[0.0001598256,0.000136911,0.00004033125,0.0003413327,0.00004079265,0.0001300282,0.0001238914,0.0001578829,0.00001332551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001604828,"about_ca_system_score_gemma":0.0002220542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003315985,"about_ca_topic_score_gemma":0.000006732195,"domain_scores_codex":[0.9987302,0.000125083,0.0003477921,0.0002448323,0.0003247227,0.0002273037],"domain_scores_gemma":[0.9993606,0.00006719299,0.0001727211,0.000188407,0.00008152302,0.0001295666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002696669,0.0006480878,0.02485026,0.0002275746,0.0003462841,0.00004181156,0.004357832,0.0007305442,0.9215511,0.001550464,0.0009695351,0.04202982],"study_design_scores_gemma":[0.01132635,0.004234337,0.5341817,0.0003732555,0.00005368876,0.00005614352,0.007384369,0.005492515,0.1355452,0.0007968851,0.2994885,0.001067034],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987887,0.0001321952,0.00001534791,0.0003693013,0.0002085893,0.0003410124,0.00001562794,0.00004283236,0.00008639324],"genre_scores_gemma":[0.9990081,0.00006244847,0.0001839052,0.000181655,0.0001010887,0.00007294868,0.0001324723,0.00002478888,0.0002325962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7860059,"threshold_uncertainty_score":0.9995815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007191580501633762,"score_gpt":0.2248028856979684,"score_spread":0.2176113051963346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}