{"id":"W4303613732","doi":"10.3390/biomedicines10102496","title":"Model of Acute Liver Failure in an Isolated Perfused Porcine Liver—Challenges and Lessons Learned","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; Translational Research in Oncology; University of Alberta","funders":"Edmonton Civic Employees Charitable Assistance Fund; University Hospital Foundation; Canadian Donation and Transplantation Research Program","keywords":"Acetaminophen; Medicine; Liver transplantation; Perfusion; Machine perfusion; Liver disease; Transplantation; Liver injury; Gastroenterology; Internal medicine; Anesthesia; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001858749,0.0001392657,0.0003622703,0.0003701622,0.00005418128,0.00000302666,0.0000885808,0.00007060923,0.0001508228],"category_scores_gemma":[0.000008002513,0.0001143803,0.00003934669,0.0002173973,0.0001019073,0.00007493143,0.00004266826,0.0001826654,8.984417e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002863065,"about_ca_system_score_gemma":0.00005410888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007467032,"about_ca_topic_score_gemma":0.00008796371,"domain_scores_codex":[0.9990404,0.00004869903,0.0002591928,0.0002537028,0.000237176,0.0001608473],"domain_scores_gemma":[0.9995303,0.00003395814,0.00007903775,0.000201887,0.00005750211,0.00009729325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00417542,0.001978439,0.06062851,0.003714951,0.0005278644,0.001814123,0.05576525,0.00006757276,0.7620537,0.004478304,0.002045534,0.1027503],"study_design_scores_gemma":[0.04150419,0.02186772,0.5771343,0.001578329,0.004127383,0.002205365,0.03068765,0.2583116,0.04874643,0.002392333,0.009221844,0.00222287],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820203,0.003675542,0.0002864246,0.01335742,0.00004315388,0.0003284265,0.0000773306,0.0001136549,0.00009770437],"genre_scores_gemma":[0.9799278,0.01787593,0.001416372,0.0003375362,0.00003578301,0.00001767696,0.00009203124,0.0000197376,0.0002771484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7133073,"threshold_uncertainty_score":0.4664293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07547153314804,"score_gpt":0.3221524266196039,"score_spread":0.2466808934715639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}