{"id":"W4303614933","doi":"10.26443/mjm.v21i1.907","title":"SARS-CoV-2 Epitope Presentation by Class II HLA Genotypes Common in North American Populations: A Proposed Computational Approach for Vaccine Efficacy Evaluation","year":2022,"lang":"en","type":"article","venue":"McGill Journal of Medicine","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"","keywords":"Human leukocyte antigen; Immunology; Ethnic group; Medicine; Context (archaeology); Epitope; Allele; Vaccination; Peptide vaccine; Genotype; Disease; Antigen; Gene; Genetics; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009909837,0.0005881033,0.0009584589,0.001160036,0.0005682977,0.001058387,0.001456229,0.001034024,0.002993673],"category_scores_gemma":[0.003918715,0.0004454288,0.001125235,0.0008828115,0.0003149498,0.0003982066,0.0007236935,0.0005373609,0.0002518162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008746018,"about_ca_system_score_gemma":0.002022076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02739733,"about_ca_topic_score_gemma":0.02123974,"domain_scores_codex":[0.9997444,0.0001353361,0.00001697258,0.00004706451,0.00002729947,0.00002902128],"domain_scores_gemma":[0.9988866,0.0008043746,0.00006309554,0.00004480143,0.0001409032,0.00006025151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001677935,0.0001355344,0.01475589,0.0000682708,0.0001632218,0.0001686241,0.00006398182,0.9709265,0.0003590902,0.001257979,0.0006831018,0.01124995],"study_design_scores_gemma":[0.00002508211,0.0000259864,0.0009058796,0.000006166869,0.00002863369,0.00002263844,0.00002725129,0.9979247,0.00004120205,0.000853048,0.0001347828,0.000004512961],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8804389,0.0008746926,0.1053812,0.0018828,0.00009270508,0.000399502,0.002865646,0.0005288409,0.007535713],"genre_scores_gemma":[0.9546963,0.0003559456,0.04108226,0.0003517942,0.00005693796,0.0005219642,0.001526813,0.0000371379,0.001370894],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.02739733,"threshold_uncertainty_score":0.05447572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05107645198673084,"score_gpt":0.3324445896408478,"score_spread":0.2813681376541169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}