{"id":"W4303628861","doi":"10.3390/cells11193134","title":"Direct Differentiation of Human Embryonic Stem Cells to 3D Functional Hepatocyte-like Cells in Alginate Microencapsulation Sphere","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Liver physiology and pathology","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Natural Science Foundation of China","keywords":"Embryonic stem cell; Hepatocyte; Bioartificial liver device; Cell biology; Induced pluripotent stem cell; Biology; Stem cell; Transplantation; Biochemistry; In vitro; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000208175,0.0001559162,0.0003585146,0.0001724144,0.0001229708,0.00000426031,0.0001032351,0.00009408249,0.001434202],"category_scores_gemma":[0.000001802245,0.0001603088,0.00009582854,0.000261723,0.00004712495,0.00004687159,0.0001161502,0.0002611545,0.0001170331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001485334,"about_ca_system_score_gemma":0.00006968902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005994951,"about_ca_topic_score_gemma":0.00001880814,"domain_scores_codex":[0.9986403,0.0002459929,0.0003154804,0.0003560313,0.0001944868,0.0002477223],"domain_scores_gemma":[0.9993758,0.00007058872,0.0001489498,0.0002756983,0.00005750101,0.0000714368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002347627,0.0002710578,0.00646382,0.00009004541,0.00003195787,0.00002411592,0.0006123126,0.001840303,0.9876144,0.00004271786,0.002466802,0.0003077119],"study_design_scores_gemma":[0.001510244,0.0007151004,0.09927264,0.00003545629,0.00008091095,0.000008301511,0.0001983455,0.0005353646,0.89506,0.00007349719,0.002325456,0.0001846906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971166,0.0001241917,0.0001475757,0.00005393625,0.0009706827,0.0005034589,0.00005188276,0.00003119849,0.00100043],"genre_scores_gemma":[0.9935653,0.00000994711,0.0001016852,0.0002897926,0.00007722059,0.0000498217,0.0001297462,0.00002094852,0.005755551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09280882,"threshold_uncertainty_score":0.9994786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01816922938255061,"score_gpt":0.2350144732852125,"score_spread":0.2168452439026619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}