{"id":"W4303628861","doi":"10.3390/cells11193134","title":"Direct Differentiation of Human Embryonic Stem Cells to 3D Functional Hepatocyte-like Cells in Alginate Microencapsulation Sphere","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Liver physiology and pathology","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Natural Science Foundation of China","keywords":"Embryonic stem cell; Hepatocyte; Bioartificial liver device; Cell biology; Induced pluripotent stem cell; Biology; Stem cell; Transplantation; Biochemistry; In vitro; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808963,0.0004738577,0.00024618,0.0002480799,0.0001116888,0.0003159657,0.0001751615,0.0002904814,0.0004404198],"category_scores_gemma":[0.0001268202,0.0001619389,0.0004951318,0.0001938701,0.0002037203,0.00018102,0.0002923905,0.000290575,0.000315876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003743325,"about_ca_system_score_gemma":0.0003270728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079329,"about_ca_topic_score_gemma":0.001659537,"domain_scores_codex":[0.9998517,0.00001081231,0.00002260995,0.00003273798,0.00005975353,0.00002242113],"domain_scores_gemma":[0.9999002,0.00001454093,0.00003086947,0.00001090602,0.00002401882,0.00001934288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000217769,0.000007431149,0.0001748798,0.00005907412,0.000004988666,0.00005002241,0.00002538116,0.0003524294,0.9974871,0.00009161313,0.00002807748,0.001697338],"study_design_scores_gemma":[0.000006004468,0.0001019068,0.001206954,0.000006891166,0.00002279371,0.0001007436,0.00001126504,0.002355871,0.9938865,0.00003031422,0.002262568,0.00000815235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644576,0.001521981,0.02986607,0.00008556728,0.00008578879,0.0001273873,0.000436706,0.0002640078,0.00315499],"genre_scores_gemma":[0.96698,0.001216254,0.02798025,0.00006538047,0.00001368938,0.00009046371,0.0004687734,0.00005092099,0.003134119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079329,"threshold_uncertainty_score":0.002716005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01816922938255061,"score_gpt":0.2350144732852125,"score_spread":0.2168452439026619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}