{"id":"W4303649156","doi":"10.1002/jat.4403","title":"Preclinical safety evaluation of Lipase OF from <i>Candida cylindracea</i>","year":2022,"lang":"en","type":"article","venue":"Journal of Applied Toxicology","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Intertek (Canada)","funders":"","keywords":"Lipase; Triglyceride; Toxicity; Triacylglycerol lipase; Body weight; Food science; Chemistry; Biology; Enzyme; Pharmacology; Biochemistry; Medicine; Internal medicine; Endocrinology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001442928,0.00007527059,0.0002876255,0.00006466419,0.00004000977,0.000002183142,0.000194452,0.0001072032,0.0003618769],"category_scores_gemma":[0.0001706442,0.00007073077,0.0001392128,0.0001047353,0.0000685338,0.000003054261,0.0001185109,0.0001487578,6.636222e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003615488,"about_ca_system_score_gemma":0.0002888742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003147136,"about_ca_topic_score_gemma":0.000009828722,"domain_scores_codex":[0.9985088,0.0001845273,0.0007325815,0.0001430473,0.000341686,0.00008935693],"domain_scores_gemma":[0.9984924,0.00006497341,0.000915861,0.0002055094,0.0002796423,0.00004158085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001212846,0.0003657789,0.0006099202,0.000006616921,0.0001559107,6.932511e-7,0.00009681664,0.01048896,0.9809412,0.0001495158,0.001103934,0.004867759],"study_design_scores_gemma":[0.003050055,0.00158978,0.004172522,0.00000606761,0.0003361189,0.00001684214,0.0003574411,0.0004715144,0.9760149,0.0007250514,0.01315297,0.0001067714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967681,0.000652771,0.0006135576,0.00008080348,0.0002297765,0.0001501736,0.00005010166,9.435183e-7,0.001453788],"genre_scores_gemma":[0.9989522,0.0001002059,0.0004674489,0.0001427626,0.0001638988,0.00001098717,0.0001299978,0.000009406454,0.00002310424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01204904,"threshold_uncertainty_score":0.3962298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02120980898291017,"score_gpt":0.2998201341023388,"score_spread":0.2786103251194286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}