{"id":"W4303649156","doi":"10.1002/jat.4403","title":"Preclinical safety evaluation of Lipase OF from <i>Candida cylindracea</i>","year":2022,"lang":"en","type":"article","venue":"Journal of Applied Toxicology","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Intertek (Canada)","funders":"","keywords":"Lipase; Triglyceride; Toxicity; Triacylglycerol lipase; Body weight; Food science; Chemistry; Biology; Enzyme; Pharmacology; Biochemistry; Medicine; Internal medicine; Endocrinology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008015725,0.001036331,0.0006469952,0.0006954442,0.0003076542,0.0005774039,0.0006600778,0.0009529295,0.002186253],"category_scores_gemma":[0.0005114934,0.0002838192,0.0008489677,0.0004557766,0.0004273806,0.0004378003,0.0002554683,0.001428677,0.000636337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006055254,"about_ca_system_score_gemma":0.0009880366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391964,"about_ca_topic_score_gemma":0.002423572,"domain_scores_codex":[0.999427,0.0001280667,0.00004671505,0.0001019998,0.0001915392,0.0001047636],"domain_scores_gemma":[0.9993783,0.00006584604,0.0002173213,0.00006679806,0.0001650055,0.0001066535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006957988,0.003246941,0.001012314,0.000331812,0.0001203444,0.0001964266,0.00006429286,0.0007170747,0.9755128,0.0003363362,0.0007400943,0.0107636],"study_design_scores_gemma":[0.0007929273,0.08942121,0.006245061,0.00006630459,0.0004574098,0.0005878304,0.000136503,0.001027705,0.8872028,0.0002271943,0.01379273,0.00004241486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804452,0.003425964,0.006868273,0.000390315,0.0001744685,0.0007729446,0.002928238,0.0002385049,0.004756058],"genre_scores_gemma":[0.9792488,0.003887626,0.003491577,0.0003400136,0.00006074763,0.0006911239,0.005018211,0.00005841875,0.007203596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002186253,"threshold_uncertainty_score":0.007313669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02120980898291017,"score_gpt":0.2998201341023388,"score_spread":0.2786103251194286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}