{"id":"W4303649374","doi":"10.1007/s40261-022-01209-8","title":"The Effect of Years-Long Exposure to Low-Dose Colchicine on Renal and Liver Function and Blood Creatine Kinase Levels: Safety Insights from the Low-Dose Colchicine 2 (LoDoCo2) Trial","year":2022,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Hartstichting; Medical Research Council; ZonMw; Teva Pharmaceutical Industries","keywords":"Medicine; Colchicine; Renal function; Internal medicine; Creatinine; Creatine kinase; Blood urea nitrogen; Placebo; Liver function; Liver function tests; Bilirubin; Gastroenterology; Coronary artery disease; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001638631,0.0003132185,0.0008796062,0.000133913,0.0002123028,0.0006788504,0.0002244705,0.0005586743,0.001708937],"category_scores_gemma":[0.001893042,0.00009297058,0.0007040909,0.0002666049,0.0003318742,0.0002340954,0.000230693,0.0007998279,0.0002035236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004414412,"about_ca_system_score_gemma":0.000376546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005526395,"about_ca_topic_score_gemma":0.002061811,"domain_scores_codex":[0.9991695,0.0005680271,0.00005789215,0.000071027,0.00006736127,0.000066172],"domain_scores_gemma":[0.9982998,0.0006009354,0.00064555,0.00009299321,0.0001323516,0.0002284446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7677596,0.002375114,0.08433284,0.005786822,0.009752387,0.0002238916,0.000243591,0.000801576,0.01481401,0.0003195643,0.005324026,0.1082667],"study_design_scores_gemma":[0.2484976,0.2385727,0.4634327,0.001352306,0.01571151,0.0009709477,0.0004112814,0.001395769,0.006916841,0.0007769267,0.02182732,0.0001341015],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682769,0.02751444,0.000216878,0.0007224667,0.0001313745,0.0001754522,0.000898712,0.00001305304,0.002050713],"genre_scores_gemma":[0.9945059,0.003583073,0.0001639603,0.0004780641,0.0001374151,0.0001215263,0.0005936571,0.000004145786,0.0004122222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001708937,"threshold_uncertainty_score":0.008666039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128010725083666,"score_gpt":0.2588416079498216,"score_spread":0.246040535441455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}