{"id":"W4303649374","doi":"10.1007/s40261-022-01209-8","title":"The Effect of Years-Long Exposure to Low-Dose Colchicine on Renal and Liver Function and Blood Creatine Kinase Levels: Safety Insights from the Low-Dose Colchicine 2 (LoDoCo2) Trial","year":2022,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Hartstichting; Medical Research Council; ZonMw; Teva Pharmaceutical Industries","keywords":"Medicine; Colchicine; Renal function; Internal medicine; Creatinine; Creatine kinase; Blood urea nitrogen; Placebo; Liver function; Liver function tests; Bilirubin; Gastroenterology; Coronary artery disease; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001121191,0.0001755382,0.0002608831,0.00002959682,0.0003875477,0.00002888654,0.0001625798,0.000109252,0.00001684977],"category_scores_gemma":[0.001231244,0.0001152093,0.00009356212,0.0001459684,0.0003196224,0.000009292694,0.0002157135,0.0003183883,0.000002797788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001107914,"about_ca_system_score_gemma":0.00006928435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008864702,"about_ca_topic_score_gemma":0.0001545987,"domain_scores_codex":[0.9976684,0.001007124,0.0005718214,0.0003851535,0.0002193451,0.0001481841],"domain_scores_gemma":[0.9983926,0.0008282373,0.0002337474,0.0003912551,0.00006116239,0.00009293183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1864202,0.0007611705,0.05253641,0.0001412934,0.0009845163,0.00002765126,0.002436025,0.001239492,0.6965303,0.0006725281,0.006267434,0.05198292],"study_design_scores_gemma":[0.06401943,0.02255571,0.7984115,0.0001962455,0.0004793921,0.000004916776,0.0004127397,0.0003625943,0.1048699,0.0005500783,0.007693173,0.0004442869],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965113,0.001262558,0.00001492677,0.0007071738,0.0003402815,0.001063771,0.00004196354,0.000009077426,0.00004895941],"genre_scores_gemma":[0.9977923,0.000233329,0.00001908926,0.000972302,0.000383926,0.00009233863,0.0003041109,0.00001881934,0.0001837766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7458751,"threshold_uncertainty_score":0.46981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128010725083666,"score_gpt":0.2588416079498216,"score_spread":0.246040535441455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}