{"id":"W4303685488","doi":"10.3390/biomedicines10102515","title":"Therapeutic Antiaging Strategies","year":2022,"lang":"en","type":"review","venue":"Biomedicines","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trent University","funders":"Agencia Nacional de Investigación y Desarrollo; King Khalid University; Deanship of Scientific Research, King Khalid University","keywords":"Proteostasis; Epigenetics; Senescence; Biology; Organism; Telomere; Genome instability; Proteotoxicity; Bioinformatics; Cellular senescence; Stem cell; Premature aging; Progeria; Neuroscience; DNA damage; Physiology; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002405836,0.0004404681,0.0007873151,0.0001757648,0.0001577706,0.00005513003,0.0005392689,0.0002528814,0.00029375],"category_scores_gemma":[0.00002273458,0.0003543576,0.0003057769,0.0002196488,0.0001792547,0.000002642682,0.0002395791,0.0002241498,0.00002696571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002416294,"about_ca_system_score_gemma":0.0003803578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002539416,"about_ca_topic_score_gemma":0.000007170141,"domain_scores_codex":[0.9982797,0.0001387915,0.0004085806,0.0005698475,0.0002538938,0.0003491763],"domain_scores_gemma":[0.998996,0.00002670525,0.0002211927,0.0006387553,0.00002981573,0.00008755198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003869203,0.00005871405,0.000008991297,0.004237853,0.0003503543,0.00001861225,0.0001509457,0.00000237512,0.0007331776,0.00007735208,0.00420714,0.9901506],"study_design_scores_gemma":[0.0001295294,0.0001926259,0.000005025846,0.0003749695,0.000440225,0.00008753713,0.0002126441,0.000002211072,0.00004038859,0.00006087398,0.9980642,0.000389735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003986483,0.996567,0.0009018669,0.00004185445,0.001111936,0.0003488518,0.00003433166,0.00003846459,0.0009158452],"genre_scores_gemma":[0.0003482471,0.996249,0.0001455735,0.0002049999,0.001188508,0.0000670753,0.0008429849,0.00009434244,0.0008593145],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9938571,"threshold_uncertainty_score":0.9998909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05628550581898478,"score_gpt":0.3377077001716573,"score_spread":0.2814221943526725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}