{"id":"W4303685488","doi":"10.3390/biomedicines10102515","title":"Therapeutic Antiaging Strategies","year":2022,"lang":"en","type":"review","venue":"Biomedicines","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trent University","funders":"Agencia Nacional de Investigación y Desarrollo; King Khalid University; Deanship of Scientific Research, King Khalid University","keywords":"Proteostasis; Epigenetics; Senescence; Biology; Organism; Telomere; Genome instability; Proteotoxicity; Bioinformatics; Cellular senescence; Stem cell; Premature aging; Progeria; Neuroscience; DNA damage; Physiology; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004689359,0.001103556,0.001181855,0.001972783,0.0002876963,0.0009088901,0.001055334,0.0012969,0.00591092],"category_scores_gemma":[0.000611855,0.0002297717,0.0007665532,0.0008487566,0.000372688,0.0009895976,0.0006539118,0.00227819,0.002311667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004842987,"about_ca_system_score_gemma":0.0005625203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004736168,"about_ca_topic_score_gemma":0.001000701,"domain_scores_codex":[0.999795,0.00003567613,0.00002651043,0.00004802982,0.00006890289,0.00002588727],"domain_scores_gemma":[0.9998181,0.00008247809,0.00002720822,0.00001032338,0.00004530327,0.00001660595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001023204,0.0001971988,0.0001358656,0.01181298,0.0001289669,0.0002734901,0.00004521687,0.0003921669,0.004873571,0.005858702,0.03142472,0.9447548],"study_design_scores_gemma":[0.00003832568,0.0001897466,0.0006052293,0.002744457,0.0001403961,0.001932105,0.00003438495,0.0001468057,0.002083005,0.002519591,0.989547,0.00001908891],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003390136,0.9946733,0.0007155318,0.000401315,0.000587958,0.00002700203,0.00006168149,0.00003333266,0.003160855],"genre_scores_gemma":[0.002831861,0.9926819,0.0008899844,0.0005875356,0.0003598584,0.00005015739,0.0001557837,0.000006039612,0.002436877],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00591092,"threshold_uncertainty_score":0.01977402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05628550581898478,"score_gpt":0.3377077001716573,"score_spread":0.2814221943526725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}