{"id":"W4303709808","doi":"10.3390/ijms231911911","title":"A Screening of Epigenetic Therapeutic Targets for Non-Small Cell Lung Cancer Reveals PADI4 and KDM6B as Promising Candidates","year":2022,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Innovative Medicines Initiative; Genentech; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Deutschen Konsortium für Translationale Krebsforschung; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Diamond Light Source; McGill University; Bayer; Pfizer; Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"Epigenetics; Lung cancer; Cancer research; Adenocarcinoma; Metastasis; Transcriptome; Cancer; In silico; Biology; Gene; Medicine; Gene expression; Oncology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003862996,0.0005692597,0.0008435143,0.001228242,0.0001579135,0.0004242391,0.0004643745,0.0006084939,0.001708891],"category_scores_gemma":[0.0003429246,0.0002233024,0.0004533279,0.0007890896,0.0002146025,0.0004610652,0.0003257767,0.001047873,0.0008095503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003514798,"about_ca_system_score_gemma":0.0005400765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000502694,"about_ca_topic_score_gemma":0.001386304,"domain_scores_codex":[0.9999113,0.00001470462,0.0000111904,0.00001840907,0.00003338937,0.00001102624],"domain_scores_gemma":[0.9998895,0.00004623113,0.00001591856,0.000004002067,0.00003264955,0.0000116524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001891766,0.0000865138,0.0004238736,0.01445812,0.0001890414,0.0004023651,0.00004656452,0.00056046,0.02124286,0.002326665,0.0111501,0.9489241],"study_design_scores_gemma":[0.0001167418,0.0007812127,0.003526288,0.002299477,0.000601789,0.003184952,0.00006830231,0.0005260884,0.0197934,0.001727515,0.967333,0.0000413159],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009321678,0.9973215,0.0004261118,0.0002300353,0.00009632863,0.00001299936,0.00003289868,0.00001181586,0.0009361889],"genre_scores_gemma":[0.005701167,0.9916932,0.0007787448,0.00031957,0.00008617983,0.00002270964,0.0001125053,0.000003930996,0.001282029],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001708891,"threshold_uncertainty_score":0.005716801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03483131641734032,"score_gpt":0.3608747635495297,"score_spread":0.3260434471321894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}