{"id":"W4303946575","doi":"10.3390/cancers14194942","title":"Roles of Chromatin Remodelling and Molecular Heterogeneity in Therapy Resistance in Glioblastoma","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Azrieli Foundation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Fondation Brain Canada","keywords":"Epigenome; Epigenetics; Epigenomics; Epigenetic therapy; Chromatin; Biology; Cancer research; Chromatin remodeling; Glioblastoma; Cancer stem cell; Cancer therapy; Epigenesis; Bioinformatics; DNA methylation; Cancer; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003754744,0.0005480593,0.0008282106,0.001325439,0.0001845768,0.0006576524,0.0005545969,0.0008310003,0.002730557],"category_scores_gemma":[0.0004608481,0.0002062775,0.0002897583,0.001144154,0.0003323979,0.0008569958,0.0005798866,0.001067314,0.001380514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000548023,"about_ca_system_score_gemma":0.0007560584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009174327,"about_ca_topic_score_gemma":0.002044674,"domain_scores_codex":[0.9999031,0.00001711624,0.00001571187,0.00001806739,0.00003456112,0.00001143953],"domain_scores_gemma":[0.9998467,0.0000718834,0.0000247005,0.000004069991,0.00003608737,0.00001648637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007345941,0.00002958152,0.0001833833,0.01267578,0.00006666745,0.0002197511,0.00005230902,0.0003113381,0.002033526,0.003752166,0.02548639,0.9551158],"study_design_scores_gemma":[0.00001382309,0.00008526481,0.001170739,0.002621483,0.00008983037,0.001616087,0.00004715268,0.0000944015,0.0006355361,0.002079815,0.9915279,0.00001797953],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001140724,0.9987846,0.00007690286,0.0002348244,0.0001235767,0.000002999511,0.00001469916,0.000004622099,0.0006437525],"genre_scores_gemma":[0.0006565918,0.9984585,0.00008895432,0.0001630706,0.0001108569,0.000004286441,0.00002654362,0.000001084276,0.0004901489],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002730557,"threshold_uncertainty_score":0.009134591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02973406808226692,"score_gpt":0.3121337152963171,"score_spread":0.2823996472140502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}