{"id":"W4303958768","doi":"10.3389/fcell.2022.972111","title":"Apoptosis-mediated anti-proliferative activity of Calligonum comosum against human breast cancer cells, and molecular docking of its major polyphenolics to Caspase-3","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Nigella sativa pharmacological applications","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Deanship of Scientific Research, King Saud University; King Saud University","keywords":"Apoptosis; Polyphenol; Docking (animal); Caspase 3; Caspase; Traditional medicine; Biology; Pharmacology; Cancer research; Chemistry; Medicine; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156947,0.0001568526,0.0004353515,0.0001696417,0.0001257953,0.000002758268,0.00009290693,0.00007756503,0.00007608237],"category_scores_gemma":[0.000007733737,0.0001441866,0.00002689892,0.0003224194,0.0001694316,0.00002089685,0.0002785073,0.0002142146,7.178998e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000148654,"about_ca_system_score_gemma":0.0001057088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001302232,"about_ca_topic_score_gemma":0.000009715754,"domain_scores_codex":[0.9989499,0.0001032994,0.0002893106,0.0003213439,0.0001020982,0.0002340034],"domain_scores_gemma":[0.9995835,0.00004336861,0.0001233773,0.00007451964,0.00004697635,0.0001282422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001601,0.0002466956,0.1043356,0.00006688006,0.0000624116,0.000006102087,0.000645733,0.00002116441,0.8927124,0.00003278565,0.000513302,0.00119688],"study_design_scores_gemma":[0.001374052,0.0001765645,0.03628991,0.0000195503,0.00002764217,0.000008027258,0.0008889859,0.0001363545,0.9604145,0.00005856112,0.0004338045,0.0001720703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972939,0.0004467443,0.0001681327,0.0004581349,0.0001138488,0.0006408916,0.0004387591,0.00001269224,0.0004269264],"genre_scores_gemma":[0.9958361,0.000274587,0.003029314,0.0005941566,0.00001117324,0.0001490156,0.00007078534,0.00001189704,0.00002295854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06804568,"threshold_uncertainty_score":0.5879758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359404108472162,"score_gpt":0.2750241268121257,"score_spread":0.2614300857274041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}