{"id":"W4303958768","doi":"10.3389/fcell.2022.972111","title":"Apoptosis-mediated anti-proliferative activity of Calligonum comosum against human breast cancer cells, and molecular docking of its major polyphenolics to Caspase-3","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Nigella sativa pharmacological applications","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Deanship of Scientific Research, King Saud University; King Saud University","keywords":"Apoptosis; Polyphenol; Docking (animal); Caspase 3; Caspase; Traditional medicine; Biology; Pharmacology; Cancer research; Chemistry; Medicine; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005021195,0.0002752791,0.0001336535,0.0002138774,0.0001207308,0.0001087049,0.0001387718,0.0001803957,0.0008107016],"category_scores_gemma":[0.00006300445,0.00006844146,0.0001848094,0.0001339474,0.0001179588,0.0001053765,0.0001218162,0.0003032052,0.000132492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001318443,"about_ca_system_score_gemma":0.0001006011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005420633,"about_ca_topic_score_gemma":0.0008954266,"domain_scores_codex":[0.9999676,0.000004995599,0.000002529291,0.000008508977,0.000008692238,0.000007683635],"domain_scores_gemma":[0.9999812,0.000003659097,0.000004308946,0.000002608466,0.000003648466,0.000004530122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000152088,0.00004784179,0.0001071607,0.000105676,0.000006480045,0.00006983375,0.00001724249,0.00006454957,0.9960368,0.00007098178,0.00004528793,0.00327599],"study_design_scores_gemma":[0.00003996639,0.0006137023,0.006725507,0.00001326605,0.00002423721,0.0003227295,0.0000236981,0.0005261989,0.9880182,0.00005681024,0.003630776,0.000004928138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881215,0.007742535,0.001327584,0.000153752,0.00003869923,0.00004407065,0.0002641018,0.00005379387,0.002253805],"genre_scores_gemma":[0.9958035,0.00182632,0.0008336706,0.00005957753,0.000009751751,0.00002370805,0.0003170801,0.000004148299,0.00112233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008107016,"threshold_uncertainty_score":0.002712131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359404108472162,"score_gpt":0.2750241268121257,"score_spread":0.2614300857274041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}