{"id":"W4303961679","doi":"10.3390/pharmaceutics14102129","title":"Delivery of RNAs to Specific Organs by Lipid Nanoparticles for Gene Therapy","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Genetic enhancement; Gene delivery; CRISPR; Spleen; Gene; Biology; Computational biology; DNA; Medicine; Bioinformatics; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002702477,0.0008389945,0.0008932137,0.001644532,0.0002011681,0.0006876781,0.0004638583,0.0007040788,0.002926922],"category_scores_gemma":[0.0002163973,0.0002653252,0.0004625621,0.001091189,0.0002432498,0.0007822619,0.0005088205,0.001114912,0.002244794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003827815,"about_ca_system_score_gemma":0.0005036773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004729834,"about_ca_topic_score_gemma":0.0009377648,"domain_scores_codex":[0.9998909,0.00001493992,0.00001032331,0.00001888047,0.00004794482,0.00001700896],"domain_scores_gemma":[0.9999435,0.00002219735,0.000009805928,0.000002571148,0.00001580725,0.000006112562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000602876,0.0001014995,0.0001148583,0.0207574,0.0000944263,0.0003226429,0.00007878583,0.0006729555,0.02865076,0.006701551,0.02027971,0.922165],"study_design_scores_gemma":[0.0000114832,0.00009509426,0.0003207549,0.001455381,0.00007602109,0.001047198,0.00003190813,0.0001610604,0.005639382,0.001439607,0.9897034,0.00001882142],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005689379,0.9951893,0.0008294429,0.0001889726,0.0002191765,0.00001449704,0.00003674002,0.0000285078,0.002924429],"genre_scores_gemma":[0.002124826,0.9951752,0.0006375498,0.0001303221,0.00006394755,0.00001799171,0.00005101296,0.000004585163,0.001794473],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002926922,"threshold_uncertainty_score":0.009791493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1375234016079487,"score_gpt":0.3846846398933721,"score_spread":0.2471612382854234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}