{"id":"W4303961679","doi":"10.3390/pharmaceutics14102129","title":"Delivery of RNAs to Specific Organs by Lipid Nanoparticles for Gene Therapy","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Genetic enhancement; Gene delivery; CRISPR; Spleen; Gene; Biology; Computational biology; DNA; Medicine; Bioinformatics; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001872806,0.0003151959,0.0006047301,0.00006992661,0.00007570163,0.00001921416,0.0005178286,0.0001515212,0.0002078191],"category_scores_gemma":[0.00001653825,0.0002914797,0.0003817572,0.0001576289,0.000040975,0.000002498215,0.0001876749,0.0001384154,0.00002418735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003462498,"about_ca_system_score_gemma":0.000155652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003150793,"about_ca_topic_score_gemma":9.373983e-7,"domain_scores_codex":[0.9985506,0.00009266516,0.0004590736,0.0004407197,0.0001512646,0.0003056586],"domain_scores_gemma":[0.9991495,0.00004641914,0.0001979248,0.0004037061,0.00008474154,0.0001176941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007622789,0.0001026051,0.000001433275,0.00054969,0.0002299265,0.000001174349,0.00002705254,0.000004078172,0.3175516,0.000002417529,0.0310185,0.6504353],"study_design_scores_gemma":[0.0002003309,0.0002622733,6.462969e-8,0.00007263618,0.0001047302,0.000006455387,0.0000126417,0.000001505091,0.3423803,0.000001732303,0.6567485,0.0002088379],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006890194,0.9906406,0.0001664963,0.00002887476,0.0005439905,0.0007952084,0.0008598244,0.00001014394,0.00006468202],"genre_scores_gemma":[0.0002885571,0.9970295,0.0002462522,0.0004588074,0.0004051117,0.0002124309,0.0007665372,0.00007466783,0.0005181483],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6502265,"threshold_uncertainty_score":0.9999537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1375234016079487,"score_gpt":0.3846846398933721,"score_spread":0.2471612382854234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}