{"id":"W4303985788","doi":"10.1158/1541-7786.mcr-22-0163","title":"Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer","year":2022,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Metalloenzymes and iron-sulfur proteins","field":"Energy","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of Ottawa; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Genome British Columbia; Scheme for Promotion of Academic and Research Collaboration; Canada Foundation for Innovation; Canadian Institutes of Health Research; Genome Canada","keywords":"Aconitase; Iron homeostasis; Cancer research; Cancer; Homeostasis; Lung cancer; Cell; Biology; Cell growth; Mitochondrion; Medicine; Cell biology; Gene; Oncology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055943,0.000208683,0.0001204616,0.0002441969,0.0001828017,0.0002875529,0.0001520858,0.0002670888,0.001032154],"category_scores_gemma":[0.0001839046,0.0001236429,0.0001212524,0.0002146578,0.0001790493,0.0001378621,0.0001461658,0.0004996722,0.000203729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003929922,"about_ca_system_score_gemma":0.0002593844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00201867,"about_ca_topic_score_gemma":0.002311385,"domain_scores_codex":[0.9999535,0.00000650632,0.000003264347,0.000009696701,0.00001678949,0.00001024329],"domain_scores_gemma":[0.9998809,0.00001535357,0.00004618759,0.000005810398,0.00002700552,0.00002468481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008845034,0.0001148754,0.01364138,0.0001164462,0.00003451825,0.0003482285,0.00004127485,0.0001933697,0.9794279,0.0001286951,0.0004146557,0.004654001],"study_design_scores_gemma":[0.0001186767,0.0009626852,0.4232378,0.00002397009,0.0001412741,0.002481454,0.0002475835,0.005293693,0.5606692,0.0006118627,0.00618929,0.00002259943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934356,0.003997875,0.0009275692,0.0003626778,0.00003447319,0.00001946016,0.0002947426,0.00007592508,0.0008517758],"genre_scores_gemma":[0.997209,0.001046236,0.00020368,0.00004903107,0.000009103434,0.00001068855,0.0003252923,0.000004107972,0.001142819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00201867,"threshold_uncertainty_score":0.004013896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02573119361121776,"score_gpt":0.3155126204360986,"score_spread":0.2897814268248808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}