{"id":"W4304014154","doi":"10.1016/j.ccell.2022.09.010","title":"A STING operation to expose KRAS and STK11 co-mutated lung cancers","year":2022,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"EMD Serono; Genentech; European Society for Medical Oncology; Moderna; Mirati Therapeutics; Chugai Pharmaceutical; Society for Immunotherapy of Cancer; Roche; Sanofi; MedImmune; Arrowhead Pharmaceuticals; Merck; GlaxoSmithKline; McGill University; Takeda Pharmaceuticals U.S.A.; Spectrum Pharmaceuticals; University of Texas MD Anderson Cancer Center; Université de Montréal; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; AstraZeneca; Boehringer Ingelheim","keywords":"STK11; KRAS; Cancer research; Lung cancer; Biology; Sting; Medicine; Mutation; Oncology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001331008,0.0003267869,0.0004113866,0.0001300823,0.0003172867,0.00004804215,0.0002602795,0.0004642065,0.01347607],"category_scores_gemma":[0.00002207102,0.0003243168,0.00007609041,0.00008643281,0.00009168346,0.00007683233,0.0001508893,0.001251805,0.0001690434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008979947,"about_ca_system_score_gemma":0.0004395982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003326453,"about_ca_topic_score_gemma":0.0001534232,"domain_scores_codex":[0.9982876,0.0003440902,0.0003149099,0.0005138671,0.0000537138,0.0004858079],"domain_scores_gemma":[0.9993702,0.0001244446,0.0001400282,0.0002834327,0.00005854177,0.00002340644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003278409,0.000008529489,0.00004063898,0.00009792661,0.000132676,0.00004707661,0.001354549,0.00003639451,0.152328,0.000001329867,0.8443903,0.001234694],"study_design_scores_gemma":[0.0007023443,0.0002801779,0.0000334148,0.0000758598,0.00007549618,0.0000292869,0.0003972616,0.000007999291,0.09880307,6.484333e-7,0.8992324,0.0003620467],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.4807143,0.2435692,0.0001512898,0.2129382,0.01938232,0.004408615,0.003107441,0.0006278955,0.03510076],"genre_scores_gemma":[0.1207438,0.002565163,0.00004092632,0.6878932,0.0009722867,0.001072369,0.003123769,0.0002086576,0.1833798],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.474955,"threshold_uncertainty_score":0.9999209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573537011950093,"score_gpt":0.2777327479748359,"score_spread":0.261997377855335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}