{"id":"W4304014154","doi":"10.1016/j.ccell.2022.09.010","title":"A STING operation to expose KRAS and STK11 co-mutated lung cancers","year":2022,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"EMD Serono; Genentech; European Society for Medical Oncology; Moderna; Mirati Therapeutics; Chugai Pharmaceutical; Society for Immunotherapy of Cancer; Roche; Sanofi; MedImmune; Arrowhead Pharmaceuticals; Merck; GlaxoSmithKline; McGill University; Takeda Pharmaceuticals U.S.A.; Spectrum Pharmaceuticals; University of Texas MD Anderson Cancer Center; Université de Montréal; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; AstraZeneca; Boehringer Ingelheim","keywords":"STK11; KRAS; Cancer research; Lung cancer; Biology; Sting; Medicine; Mutation; Oncology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007170892,0.0003634975,0.0004115394,0.0002611873,0.0009654679,0.001020169,0.0004653909,0.01056318,0.003621493],"category_scores_gemma":[0.002395297,0.0003210102,0.0007972733,0.0001331805,0.0009883455,0.0006413088,0.0005351418,0.009426391,0.001499102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001281012,"about_ca_system_score_gemma":0.0005681287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006174595,"about_ca_topic_score_gemma":0.001207375,"domain_scores_codex":[0.9995922,0.00009057618,0.00003883122,0.00004676717,0.0001247253,0.000106853],"domain_scores_gemma":[0.9992862,0.0004223615,0.00004297146,0.00006300351,0.00004891758,0.0001365211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001600528,0.000554411,0.006026936,0.0001927398,0.0001545439,0.08868235,0.0002580032,0.0005507271,0.03931672,0.01940602,0.7692018,0.07405528],"study_design_scores_gemma":[0.001520487,0.0014532,0.00768771,0.0001899392,0.0001600329,0.09844857,0.0005185455,0.003550074,0.02824744,0.02481426,0.8333234,0.00008639479],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.04658525,0.006909938,0.00197913,0.8811251,0.03600139,0.00009700382,0.0001724785,0.0002829356,0.02684679],"genre_scores_gemma":[0.3066706,0.005086135,0.002468956,0.574331,0.06098531,0.0001876844,0.0001432503,0.00009037388,0.05003671],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01056318,"threshold_uncertainty_score":0.01211506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573537011950093,"score_gpt":0.2777327479748359,"score_spread":0.261997377855335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}