{"id":"W4304080455","doi":"10.1038/s41591-022-02026-4","title":"Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":787,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; York University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Novo Nordisk; National Institute for Health and Care Research","keywords":"Semaglutide; Medicine; Placebo; Overweight; Discontinuation; Weight loss; Internal medicine; Body mass index; Obesity; Randomized controlled trial; Adverse effect; Confidence interval; Weight change; Physical therapy; Diabetes mellitus; Type 2 diabetes; Liraglutide; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001271245,0.0006540044,0.001402628,0.0001826983,0.0002527199,0.0006765418,0.0004032141,0.001229048,0.005135241],"category_scores_gemma":[0.001516216,0.0002015928,0.001732581,0.0001799005,0.0003067062,0.0006101333,0.0003873843,0.001818995,0.0005230645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003389614,"about_ca_system_score_gemma":0.0004703117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006611018,"about_ca_topic_score_gemma":0.001525807,"domain_scores_codex":[0.9995102,0.0002562103,0.00004628045,0.0000604611,0.0000540238,0.00007298157],"domain_scores_gemma":[0.9994561,0.000171421,0.0001377268,0.00003422248,0.00004886462,0.0001516808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9467046,0.003578364,0.004447763,0.002224619,0.003648134,0.0001074271,0.00007717864,0.000470174,0.001935331,0.0003063475,0.002779191,0.03372084],"study_design_scores_gemma":[0.858689,0.09807477,0.03210968,0.0006484583,0.004154099,0.0001296521,0.0001362332,0.00117352,0.001102675,0.0004950191,0.003239531,0.00004746483],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782422,0.01386871,0.000564947,0.0008239168,0.0006479961,0.0008028147,0.001481316,0.0001051422,0.003462878],"genre_scores_gemma":[0.9903081,0.003108899,0.0005826785,0.001148204,0.0002768792,0.001170244,0.001196323,0.00001068152,0.002198074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005135241,"threshold_uncertainty_score":0.01717907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003848795909790984,"score_gpt":0.2435443268927412,"score_spread":0.2396955309829503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}