{"id":"W4304086663","doi":"10.1371/journal.pgen.1010446","title":"A two–tiered system for selective receptor and transporter protein degradation","year":2022,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Biology; Cell biology; ESCRT; Endocytosis; Saccharomyces cerevisiae; Lysosome; Protein degradation; Transport protein; Membrane protein; Receptor; Ubiquitin; Endosome; Biochemistry; Gene; Intracellular; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001130527,0.001378279,0.001339171,0.001256315,0.0007817723,0.002610779,0.0008959434,0.001363896,0.002228091],"category_scores_gemma":[0.0005887507,0.0006730962,0.001072704,0.0003853998,0.0009198534,0.002344953,0.002102718,0.001170368,0.002531967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001670102,"about_ca_system_score_gemma":0.001123504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007841659,"about_ca_topic_score_gemma":0.0009277911,"domain_scores_codex":[0.9983982,0.0001779145,0.0001631663,0.0005135283,0.0004549006,0.0002921972],"domain_scores_gemma":[0.9990432,0.00008387903,0.0001623987,0.0003612252,0.0001904591,0.0001587789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002059606,0.00009289437,0.001578526,0.0002396686,0.00007959624,0.0003074337,0.00007940684,0.0004449794,0.9746396,0.009290425,0.0009245314,0.01211695],"study_design_scores_gemma":[0.00006156434,0.0007690148,0.01290482,0.000051454,0.0001006294,0.003675575,0.0001192061,0.01815576,0.9256989,0.007473747,0.03077599,0.0002134076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5677818,0.01421454,0.3918498,0.001742753,0.0007049264,0.0005793538,0.002051154,0.009321553,0.0117541],"genre_scores_gemma":[0.8981982,0.002985728,0.07817398,0.0006783042,0.0001074352,0.0002390589,0.001296917,0.0004219269,0.0178985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002610779,"threshold_uncertainty_score":0.01211751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153966049812944,"score_gpt":0.2054490507228527,"score_spread":0.1939093902247233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}