{"id":"W4304086666","doi":"10.1371/journal.pbio.3001543","title":"A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response","year":2022,"lang":"en","type":"article","venue":"PLoS Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; Université de Sherbrooke; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research; Fondation CHU de Québec; Fonds de Recherche du Québec - Santé; Cole Foundation; Canada Excellence Research Chairs, Government of Canada; Natural Sciences and Engineering Research Council of Canada; McMaster University; University of Pennsylvania","keywords":"Genome instability; DNA damage; Biology; DNA repair; Chromatin; DNA replication; Replication protein A; DNA; Cell biology; Molecular biology; SOS response; Genetics; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408112,0.0005110379,0.0005116567,0.000497245,0.0002248964,0.0003626931,0.000249295,0.0004397899,0.001344826],"category_scores_gemma":[0.0001658064,0.0001737655,0.0003411657,0.0005228175,0.000122691,0.00009299125,0.0001935512,0.0004229296,0.0003597212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865857,"about_ca_system_score_gemma":0.0002441688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007055303,"about_ca_topic_score_gemma":0.00197476,"domain_scores_codex":[0.999884,0.00001017623,0.000007278643,0.00004062373,0.00003894805,0.00001890895],"domain_scores_gemma":[0.9998608,0.00003260826,0.00004660145,0.000009251657,0.00001669786,0.00003401257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001906564,0.00006200212,0.003655133,0.0001063426,0.00007079554,0.0002422784,0.00001543948,0.0001987118,0.9891598,0.00003740956,0.0002754306,0.005986103],"study_design_scores_gemma":[0.0001340348,0.002426489,0.2502297,0.00004906408,0.0008216128,0.002307824,0.0001039998,0.00418389,0.724465,0.0001700562,0.01505824,0.0000500376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817409,0.006257263,0.003487388,0.0002000208,0.00003795792,0.0001035901,0.005671342,0.0004899158,0.002011722],"genre_scores_gemma":[0.9793054,0.003397939,0.004122937,0.0002675009,0.00002337047,0.00008300245,0.00929947,0.00006732201,0.003433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001344826,"threshold_uncertainty_score":0.004498899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558892925457971,"score_gpt":0.2540811501995514,"score_spread":0.2384922209449717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}