{"id":"W4304098223","doi":"10.1136/jnnp-2022-329680","title":"Brain age gap in neuromyelitis optica spectrum disorders and multiple sclerosis","year":2022,"lang":"en","type":"article","venue":"Journal of Neurology Neurosurgery & Psychiatry","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Meso Scale Diagnostics; Medical Research Council; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; University College London Hospitals NHS Foundation Trust; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Association","keywords":"Neuromyelitis optica; Multiple sclerosis; Medicine; Expanded Disability Status Scale; Spectrum disorder; Relapsing remitting; Cohort; Internal medicine; Pediatrics; Immunology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000525256,0.0002984529,0.0002888641,0.0008145603,0.0002190858,0.0003827426,0.0001975629,0.0002951332,0.0008648125],"category_scores_gemma":[0.001642333,0.0001054037,0.0002465258,0.0004211082,0.0002595739,0.0005451706,0.000544908,0.000264955,0.0001540878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003229546,"about_ca_system_score_gemma":0.0002485472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003066367,"about_ca_topic_score_gemma":0.003569366,"domain_scores_codex":[0.9997962,0.00003443761,0.00002945582,0.00006568933,0.00003931841,0.00003485568],"domain_scores_gemma":[0.9992078,0.0001313791,0.0004643165,0.00003740738,0.00007498836,0.000084049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003353297,0.00002500443,0.9953693,0.00001662272,0.00004690262,0.0001844102,0.00004435767,0.0001552292,0.0003871311,0.0000237724,0.00007530714,0.003336629],"study_design_scores_gemma":[0.000007546632,0.0001195935,0.9979057,0.00001148596,0.00002249987,0.0005626541,0.00008260432,0.0008560672,0.0001861178,0.00009733102,0.000145353,0.000003040966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992347,0.0002401519,0.00008843614,0.00002115927,0.000003028901,0.000003309144,0.0002288202,0.00000276526,0.0001777111],"genre_scores_gemma":[0.9995216,0.00005093457,0.00008337404,0.00001008508,0.000004542798,0.000003017718,0.0002669937,8.148525e-7,0.000058597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003066367,"threshold_uncertainty_score":0.006097019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04303370433814185,"score_gpt":0.2770648244002131,"score_spread":0.2340311200620712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}