{"id":"W4304118523","doi":"10.1002/jev2.12220","title":"Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA","year":2022,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta; University of Ottawa","funders":"","keywords":"Transfection; Endosome; Small interfering RNA; Microvesicles; RNA; Extracellular; Molecular biology; Cell biology; Biology; Gene delivery; Nucleic acid; Cytoplasm; RNA interference; Chemistry; Biochemistry; Intracellular; microRNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001065042,0.0007454238,0.0005015666,0.000630396,0.000299049,0.001110973,0.0002745641,0.000762145,0.001655623],"category_scores_gemma":[0.001501784,0.0003919551,0.0005321669,0.0003790529,0.0004128137,0.000826701,0.000893807,0.0006426117,0.001034865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004722436,"about_ca_system_score_gemma":0.0003980594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004681158,"about_ca_topic_score_gemma":0.0004791429,"domain_scores_codex":[0.9989335,0.0002501189,0.0001764333,0.0001912767,0.000329745,0.0001188532],"domain_scores_gemma":[0.9990307,0.0003190319,0.000256636,0.0001641127,0.0001589014,0.00007065303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004801235,0.00001364514,0.0005500141,0.0001107206,0.00002502133,0.000210858,0.00005832989,0.0000480457,0.9957191,0.0006833977,0.00008446794,0.002448357],"study_design_scores_gemma":[0.000007714361,0.00008589974,0.003392292,0.00002478754,0.00003911337,0.000908515,0.00003686962,0.0005976119,0.9847667,0.0003691892,0.009761195,0.00001010261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8770579,0.01205475,0.09822314,0.0004556508,0.0003320682,0.000365884,0.0009014502,0.0007747529,0.009834443],"genre_scores_gemma":[0.9661978,0.002389246,0.02152384,0.0002865893,0.00003469469,0.0002222845,0.001810529,0.000313731,0.007221151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655623,"threshold_uncertainty_score":0.005632579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01238707818179212,"score_gpt":0.2244073159316884,"score_spread":0.2120202377498963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}