{"id":"W4304165954","doi":"10.1038/s41467-022-33720-z","title":"Evolution and modulation of antigen-specific T cell responses in melanoma patients","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Cancer Institute; Syöpäsäätiö; K. Albin Johanssons Stiftelse; Emil Aaltosen Säätiö; Signe ja Ane Gyllenbergin Säätiö; Suomen Lääketieteen Säätiö; KAUTE-Säätiö; Blood Disease Research Foundation; Biomedicum Helsinki-säätiö; Howard Hughes Medical Institute","keywords":"Repertoire; Melanoma; T-cell receptor; Antigen; Immunology; Biology; Phenotype; TIGIT; T cell; Cancer research; Medicine; Genetics; Gene; Immune system; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002009907,0.0001265174,0.0001803553,0.0007045537,0.0002022505,0.000342509,0.0001354238,0.0003513384,0.0009541679],"category_scores_gemma":[0.0007000093,0.00009797955,0.000149969,0.0004177622,0.0001436477,0.0002387663,0.0001792006,0.0002372246,0.0002344544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001643122,"about_ca_system_score_gemma":0.0000613281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005425058,"about_ca_topic_score_gemma":0.0004824534,"domain_scores_codex":[0.9997848,0.00004733542,0.00001585098,0.00008086432,0.00002755474,0.00004370719],"domain_scores_gemma":[0.9997273,0.00006355833,0.0001060964,0.00002577172,0.00002471102,0.00005265771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004120914,0.00003330631,0.9816243,0.000009121206,0.00003991041,0.0004060799,0.0001625937,0.0001946511,0.01048781,0.0000466357,0.0001057694,0.006477688],"study_design_scores_gemma":[0.000003690931,0.0001243858,0.9968953,0.00000257907,0.00001392745,0.00121782,0.0001463912,0.0004065352,0.00089358,0.00006168965,0.000231012,0.000003129401],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996333,0.00007177442,0.00004731556,0.000009644724,0.000001121567,0.000001447223,0.00005790516,0.000002282479,0.0001752292],"genre_scores_gemma":[0.9997759,0.00002210808,0.0000313899,0.000008049148,0.000001918602,0.000001351478,0.00008934479,0.000001186128,0.00006880735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009541679,"threshold_uncertainty_score":0.003192067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03372958040194517,"score_gpt":0.3277208938570633,"score_spread":0.2939913134551181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}