{"id":"W4304165954","doi":"10.1038/s41467-022-33720-z","title":"Evolution and modulation of antigen-specific T cell responses in melanoma patients","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Cancer Institute; Syöpäsäätiö; K. Albin Johanssons Stiftelse; Emil Aaltosen Säätiö; Signe ja Ane Gyllenbergin Säätiö; Suomen Lääketieteen Säätiö; KAUTE-Säätiö; Blood Disease Research Foundation; Biomedicum Helsinki-säätiö; Howard Hughes Medical Institute","keywords":"Repertoire; Melanoma; T-cell receptor; Antigen; Immunology; Biology; Phenotype; TIGIT; T cell; Cancer research; Medicine; Genetics; Gene; Immune system; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003598014,0.00005789295,0.0001222206,0.0003074165,0.0001602257,0.000005169321,0.0002422393,0.00008055264,0.0002022193],"category_scores_gemma":[0.00007161281,0.00006196377,0.00003145748,0.0005156257,0.00008485438,0.00004505478,0.0002983272,0.0007365254,0.000001725204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201649,"about_ca_system_score_gemma":0.00006644273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000454422,"about_ca_topic_score_gemma":0.00006270581,"domain_scores_codex":[0.9989865,0.0003195871,0.00019167,0.0001229378,0.0002802402,0.00009906101],"domain_scores_gemma":[0.9986331,0.0002252372,0.00006842789,0.0009057087,0.0001341119,0.00003334535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006389886,0.0008244964,0.8465976,0.00001707859,0.00001345915,0.000001231133,0.0008586063,0.0000368626,0.1410966,0.002206413,0.0009417287,0.006767034],"study_design_scores_gemma":[0.00110545,0.0001685328,0.9497031,0.00001072128,0.000003579534,0.000003411541,0.0002131327,0.00103062,0.0008845096,0.0001475063,0.04667802,0.00005145123],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872342,0.008465159,0.00001044408,0.0008531084,0.00004458383,0.0004255167,0.00003401494,0.00001459567,0.002918349],"genre_scores_gemma":[0.9969247,0.001454624,0.0008819438,0.00004260078,0.000009832686,0.00004247899,0.0001797491,0.00001172403,0.0004523289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1402121,"threshold_uncertainty_score":0.3199877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03372958040194517,"score_gpt":0.3277208938570633,"score_spread":0.2939913134551181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}