{"id":"W4304175419","doi":"10.3389/fmolb.2022.1031756","title":"Delivery of the selenoprotein thioredoxin reductase 1 to mammalian cells","year":2022,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Selenocysteine; Selenoprotein; Thioredoxin reductase; Thioredoxin; Escherichia coli; Chemistry; Molecular biology; Biology; Biochemistry; Enzyme; Glutathione; Cysteine; Gene; Glutathione peroxidase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004272853,0.0004852809,0.0005299134,0.0002623736,0.0002586465,0.0005586316,0.000517433,0.0007158493,0.001039124],"category_scores_gemma":[0.0001397782,0.0002649369,0.0004154383,0.0003078158,0.0002854676,0.0002699449,0.0004110814,0.0009955268,0.0008516804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004212118,"about_ca_system_score_gemma":0.0002940037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004124596,"about_ca_topic_score_gemma":0.0004784462,"domain_scores_codex":[0.9996263,0.00005398006,0.00003694136,0.000124374,0.0001080367,0.00005037137],"domain_scores_gemma":[0.9999077,0.00001783357,0.00002020955,0.00002052921,0.00002074265,0.00001284186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000331436,0.00001518435,0.00003977365,0.0000651547,0.000008249765,0.000051497,0.00003793075,0.00008391791,0.9978796,0.0004450417,0.00008240294,0.001258132],"study_design_scores_gemma":[0.0000124585,0.000163761,0.0003042076,0.000007170097,0.00001779096,0.0001587424,0.00001978186,0.0008726753,0.9899338,0.00007370416,0.008430171,0.000005672322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8272675,0.007341835,0.1479619,0.0007429171,0.0005049955,0.0007393672,0.004174203,0.001301361,0.009965835],"genre_scores_gemma":[0.9162086,0.004464343,0.06364579,0.0002092667,0.00004529958,0.000405734,0.003392016,0.0001302858,0.01149858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001039124,"threshold_uncertainty_score":0.003476202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003634313641742751,"score_gpt":0.2059632940968446,"score_spread":0.2023289804551019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}