{"id":"W4304193755","doi":"10.1038/s41467-022-33510-7","title":"Whole genome sequence analysis of blood lipid levels in >66,000 individuals","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Université de Montréal; Université Laval; University of Ottawa; McGill University; University of Calgary","funders":"National Institute of Environmental Health Sciences; National Human Genome Research Institute; National Institute on Aging; National Cancer Institute; Science and Technology Facilities Council; Boston Scientific Corporation; Novo Nordisk Fonden; Yale University; Invitae; Bristol-Myers Squibb; AstraZeneca; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Pfizer; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen; Regeneron Pharmaceuticals; U.S. Department of Veterans Affairs; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Genetics; Biology; Gene; Mendelian inheritance; Whole genome sequencing; Dyslipidemia; Genome; Allele; Computational biology; Genome-wide association study; Single-nucleotide polymorphism; Genotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005386288,0.0002766897,0.0002669315,0.000835825,0.0004179848,0.0004388748,0.0001781406,0.0003827802,0.001875108],"category_scores_gemma":[0.0014293,0.0002393416,0.0003753316,0.0016766,0.0002201771,0.0001488953,0.0005169011,0.0004083904,0.0005959836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001472602,"about_ca_system_score_gemma":0.0003080172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006235297,"about_ca_topic_score_gemma":0.01283956,"domain_scores_codex":[0.9996957,0.00006309307,0.00002308649,0.0001396466,0.00004350983,0.00003496133],"domain_scores_gemma":[0.9995691,0.000123689,0.00008849104,0.00009304566,0.00005734838,0.00006827019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007190493,0.00006138878,0.8310974,0.0003414168,0.001393995,0.001036976,0.001201313,0.001509739,0.1100812,0.0005004406,0.006284853,0.04577227],"study_design_scores_gemma":[0.0000306984,0.00007439638,0.986668,0.00003268987,0.0002590315,0.0009487972,0.0001568915,0.0007401688,0.00216687,0.0002541112,0.008654907,0.00001339962],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743235,0.0005551,0.002098084,0.000127292,0.00001271045,0.00002621388,0.02180315,0.00007703548,0.0009768871],"genre_scores_gemma":[0.9576142,0.0006584388,0.005867958,0.0001640396,0.00002030007,0.00006972699,0.03339522,0.00008463003,0.002125353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006235297,"threshold_uncertainty_score":0.012398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04191027720859829,"score_gpt":0.3284190077022027,"score_spread":0.2865087304936044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}