{"id":"W4304588885","doi":"10.3390/ijms232012092","title":"Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer’s Disease","year":2022,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Cholinergic; Senile plaques; Alzheimer's disease; Cholinergic neuron; Amyloid (mycology); Biology; Neuroscience; Cell biology; Biochemistry; Disease; Chemistry; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003584826,0.0007554467,0.001040074,0.002247953,0.0002852037,0.0008614624,0.0005774463,0.0009900399,0.003279166],"category_scores_gemma":[0.0004296891,0.0002205801,0.000391361,0.001996716,0.0003014245,0.001020239,0.0004949084,0.001477916,0.001552809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004600515,"about_ca_system_score_gemma":0.0009328959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008501787,"about_ca_topic_score_gemma":0.001801297,"domain_scores_codex":[0.9998753,0.00001965108,0.00002244498,0.00001843275,0.00005083257,0.00001346207],"domain_scores_gemma":[0.9998568,0.00006065606,0.00002425306,0.000003900622,0.00003889747,0.00001559652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009722309,0.0001488594,0.0001747772,0.02749293,0.00009304373,0.0002638902,0.0001046197,0.0002885156,0.002892321,0.003363234,0.02580606,0.9392745],"study_design_scores_gemma":[0.000022794,0.0002156994,0.001400069,0.006139021,0.000162492,0.001672698,0.00008854804,0.00009086401,0.0004871099,0.002339584,0.9873625,0.00001857702],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001080381,0.9990395,0.00003652036,0.0001125074,0.0001335855,0.000003075541,0.000008275736,0.000003956937,0.0005545435],"genre_scores_gemma":[0.0004669909,0.9988421,0.00007944346,0.00008811562,0.0001105081,0.000004155686,0.00001322202,5.890604e-7,0.0003949251],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003279166,"threshold_uncertainty_score":0.01096994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08441426283824977,"score_gpt":0.4002800935348107,"score_spread":0.3158658306965609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}