{"id":"W4304693653","doi":"10.1128/mbio.02578-22","title":"Macrophage Mitochondrial Biogenesis and Metabolic Reprogramming Induced by Leishmania donovani Require Lipophosphoglycan and Type I Interferon Signaling","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Institut national de la recherche scientifique; Government of Canada; McGill University","keywords":"Lipophosphoglycan; Biology; Cell biology; Leishmania donovani; Mitochondrial biogenesis; Leishmania; Signal transduction; Biogenesis; Mitochondrion; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129238,0.0002013362,0.000163018,0.0001697706,0.0002343326,0.0003582059,0.0001061465,0.0002721894,0.001493608],"category_scores_gemma":[0.00008088414,0.0001132849,0.000207809,0.000131086,0.0002054305,0.0002071141,0.0003690846,0.0004415793,0.0003651426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002538002,"about_ca_system_score_gemma":0.0002041868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002100523,"about_ca_topic_score_gemma":0.000534691,"domain_scores_codex":[0.9998218,0.00003788,0.0000104104,0.00003371691,0.00002735692,0.00006877771],"domain_scores_gemma":[0.9999464,0.000003472337,0.00001375365,0.000005956729,0.00001049076,0.00002003991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005377657,0.00004292849,0.0008164514,0.00005751955,0.000006392774,0.0001477817,0.00003977004,0.00003390868,0.9957141,0.0003497173,0.000152648,0.002101021],"study_design_scores_gemma":[0.0001619539,0.0007077279,0.07180636,0.00005932094,0.00004936821,0.001533578,0.0008217871,0.001477405,0.906291,0.0009662189,0.01609924,0.00002601819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906147,0.002824435,0.001603852,0.0004746391,0.00008244593,0.00002918835,0.000447941,0.00005671951,0.00386616],"genre_scores_gemma":[0.9955791,0.0007222784,0.0005185039,0.0001317443,0.0000137945,0.00003685824,0.0003374402,0.00001078439,0.002649536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493608,"threshold_uncertainty_score":0.004996598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755505732187504,"score_gpt":0.2874724202375513,"score_spread":0.2599173629156763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}