{"id":"W4304693653","doi":"10.1128/mbio.02578-22","title":"Macrophage Mitochondrial Biogenesis and Metabolic Reprogramming Induced by Leishmania donovani Require Lipophosphoglycan and Type I Interferon Signaling","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Institut national de la recherche scientifique; Government of Canada; McGill University","keywords":"Lipophosphoglycan; Biology; Cell biology; Leishmania donovani; Mitochondrial biogenesis; Leishmania; Signal transduction; Biogenesis; Mitochondrion; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003863527,0.0002436774,0.0004920171,0.000177182,0.0004938692,0.0001006619,0.0001487361,0.00007762521,0.0002213413],"category_scores_gemma":[0.000239611,0.0002319897,0.00006686012,0.000516213,0.0001462555,0.0001287942,0.0006485207,0.0004143772,0.000009216055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001081334,"about_ca_system_score_gemma":0.00007064205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009873164,"about_ca_topic_score_gemma":0.00006648033,"domain_scores_codex":[0.997943,0.0001286435,0.0003356457,0.0006592438,0.0004577647,0.0004757252],"domain_scores_gemma":[0.9991171,0.00006884462,0.0001043963,0.0003815665,0.0001094383,0.000218608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00110476,0.0001379375,0.008808716,0.00009065373,0.0002707629,0.0001224878,0.001032106,3.777561e-7,0.9327431,0.00008493358,0.002788635,0.05281558],"study_design_scores_gemma":[0.01027002,0.007605928,0.02625748,0.0001961095,0.0006954812,0.000530682,0.008484903,0.0001876487,0.5603276,0.0002336441,0.3838138,0.001396677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813113,0.01618424,0.00001339422,0.001215448,0.0003950921,0.0005981583,0.00003317549,0.00009629507,0.0001528663],"genre_scores_gemma":[0.9966924,0.0006334847,0.0008934112,0.0002647123,0.0002281185,0.0001055772,0.00003701881,0.00005844117,0.001086829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3810251,"threshold_uncertainty_score":0.9460266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755505732187504,"score_gpt":0.2874724202375513,"score_spread":0.2599173629156763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}