{"id":"W4304695096","doi":"10.1158/1078-0432.ccr-22-2576","title":"hENT1 Expression Predicts Response to Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Ductal Adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; McGill University Health Centre; Nova Scotia Cancer Centre; Princess Margaret Cancer Centre; Cancer Care South East; Ontario Institute for Cancer Research; Dalhousie University; University of Toronto","funders":"Canadian Cancer Society Research Institute; Terry Fox Research Institute; Pancreatic Cancer Canada Foundation; Ministère des Services à l'enfance et des Services sociaux et communautaires, Gouvernement de l’Ontario; QEII Foundation; Princess Margaret Cancer Foundation","keywords":"Gemcitabine; Nab-paclitaxel; Pancreatic ductal adenocarcinoma; Paclitaxel; Medicine; Oncology; Adenocarcinoma; Internal medicine; Pancreatic cancer; Cancer research; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007224855,0.0002023035,0.0003842712,0.0003070737,0.000170052,0.0004765002,0.0001760686,0.0002986797,0.0007947967],"category_scores_gemma":[0.001305475,0.000156722,0.0003334812,0.0003686483,0.0002368298,0.0002429239,0.0002329008,0.0003188946,0.0001517451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003485828,"about_ca_system_score_gemma":0.0001846044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004844483,"about_ca_topic_score_gemma":0.0006230848,"domain_scores_codex":[0.9997388,0.000101491,0.0000261241,0.0000630247,0.00004423756,0.0000264007],"domain_scores_gemma":[0.9991835,0.0002661279,0.0003224751,0.00004902705,0.00005044787,0.0001284513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005340129,0.00009780056,0.9866959,0.00002433285,0.0000927747,0.00007257241,0.00002838498,0.0002724032,0.002805894,0.00000796067,0.00004882206,0.004513155],"study_design_scores_gemma":[0.0001683882,0.001439889,0.9943552,0.000006942375,0.0001327174,0.0004662242,0.00007498566,0.001351969,0.001664945,0.00003587025,0.0002969213,0.000005943023],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995947,0.0002235217,0.00004038896,0.00001277596,0.000002403489,0.000004234922,0.00005077907,0.000001597422,0.00006964612],"genre_scores_gemma":[0.9996516,0.00007081089,0.00007164019,0.000009960385,0.000005677302,0.000005353686,0.0001208218,9.210967e-7,0.00006327696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007947967,"threshold_uncertainty_score":0.003820896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0802004714635329,"score_gpt":0.4485903897248844,"score_spread":0.3683899182613515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}