{"id":"W4304695096","doi":"10.1158/1078-0432.ccr-22-2576","title":"hENT1 Expression Predicts Response to Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Ductal Adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; McGill University Health Centre; Nova Scotia Cancer Centre; Princess Margaret Cancer Centre; Cancer Care South East; Ontario Institute for Cancer Research; Dalhousie University; University of Toronto","funders":"Canadian Cancer Society Research Institute; Terry Fox Research Institute; Pancreatic Cancer Canada Foundation; Ministère des Services à l'enfance et des Services sociaux et communautaires, Gouvernement de l’Ontario; QEII Foundation; Princess Margaret Cancer Foundation","keywords":"Gemcitabine; Nab-paclitaxel; Pancreatic ductal adenocarcinoma; Paclitaxel; Medicine; Oncology; Adenocarcinoma; Internal medicine; Pancreatic cancer; Cancer research; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003079688,0.0001291759,0.000232467,0.0001430434,0.0002244285,0.00002193397,0.0003148577,0.0001007351,0.0001679523],"category_scores_gemma":[0.00119488,0.0001242198,0.00006218468,0.0003597857,0.0001478919,0.000006625196,0.001032765,0.0005855996,0.000005906049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007081799,"about_ca_system_score_gemma":0.0002898226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001076283,"about_ca_topic_score_gemma":0.00001858571,"domain_scores_codex":[0.996707,0.001251903,0.0004181191,0.0006680749,0.0004755243,0.0004794084],"domain_scores_gemma":[0.9987885,0.0003811048,0.00004941795,0.0004073258,0.0001091374,0.0002645543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02322415,0.0003503982,0.4109506,0.00006122317,0.00005504807,0.000203249,0.0004181251,0.0008075014,0.5191501,0.00002154987,0.04295752,0.001800526],"study_design_scores_gemma":[0.008827073,0.009818967,0.8284448,0.0002366602,0.00003481014,0.0000733715,0.002426285,0.0003357975,0.03665,0.0003458357,0.1120285,0.0007777925],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834934,0.01394064,0.00002622095,0.001766256,0.0001550485,0.0004565552,0.00004585877,0.00001235424,0.0001036223],"genre_scores_gemma":[0.9962434,0.0006165687,0.0002266941,0.0003735554,0.0003645069,0.0004751645,0.00002952556,0.00002864726,0.001641937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4825001,"threshold_uncertainty_score":0.5065537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0802004714635329,"score_gpt":0.4485903897248844,"score_spread":0.3683899182613515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}