{"id":"W4304698823","doi":"10.1038/s41586-022-05275-y","title":"A saturated map of common genetic variants associated with human height","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":895,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Dalhousie University; Montreal Heart Institute; Université de Montréal; Université Laval","funders":"Daiichi Sankyo Europe; European Social Fund; Core Research for Evolutional Science and Technology; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Biosense Webster; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Environmental Health Sciences; Fogarty International Center; National Institute of General Medical Sciences; National Cancer Institute; National Eye Institute; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; School of Public Health, Imperial College London; Tongji Medical College, Huazhong University of Science and Technology; Biomedical Research Council; National Key Research and Development Program of China; Health and Social Care Research and Development Division; Japan Society for the Promotion of Science; Cancer Council Tasmania; Cancer Council Victoria; Medical Research Council; Canadian Cancer Society Research Institute; National Health and Medical Research Council; Canadian Institutes of Health Research; Weill Cornell Medicine - Qatar; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Mental Health; Helsinki Institute of Life Science, Helsingin Yliopisto; Forsknings- og Innovationsstyrelsen; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Stanley Center for Psychiatric Research, Broad Institute; Perelman School of Medicine, University of Pennsylvania; Weill Cornell Medical College; Centers for Disease Control and Prevention; Turun Yliopistosäätiö; Ministry of Cultural Affairs; Avera Institute for Human Genetics; Diabetesforeningen; Heinz Nixdorf Stiftung; National Human Genome Research Institute; MRC-PHE Centre for Environment and Health; Ministerie van Economische Zaken, Landbouw en Innovatie; Provincia autonoma di Bolzano - Alto Adige; Freistaat Sachsen; Xarxa de Bancs de Tumors de Catalunya; Business Finland; Diabetestutkimussäätiö; Wageningen University and Research; H. Lundbeck A/S; Hjartavernd; Danish Agency for Science and Higher Education; Institut de Cardiologie de Montréal; Fondation Institut de Cardiologie de Montréal; Takeda Pharmaceutical Company; Medizinische Universität Wien; Fondation du cancer du sein du Québec; Servier; University of North Carolina at Chapel Hill; European Commission; Tays; Swedish Cancer Foundation; Stichting Blindenhulp; Medizinische Universität Graz; Egmont Fonden; Rush University; Alexandria University; Consejo Nacional de Ciencia y Tecnología; Novo Nordisk Fonden; University of Bristol; Safe Work Australia; Wake Forest School of Medicine; Karl-Franzens-Universität Graz; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Salud Carlos III; Otsuka Pharmaceutical; School of Medicine, Boston University; Yrjö Jahnssonin Säätiö; Ministeriet Sundhed Forebyggelse; Novo Nordisk; Institut National Du Cancer; Chinese Society of Clinical Oncology; Helsefonden; Lastentautien Tutkimussäätiö; Fundación IMSS; Augustinus Fonden; Astellas Pharma; Instituto Mexicano del Seguro Social; Deutsche Forschungsgemeinschaft; Taichung Veterans General Hospital; Helse Midt-Norge; Diabetes UK; University College London; Tongji University; Faculty of Medicine and Health, University of Sydney; Oesterreichische Nationalbank; Regione Campania; KU Leuven; Juho Vainion Säätiö; Hjärt-Lungfonden; Barts and The London School of Medicine and Dentistry; Emil Aaltosen Säätiö; National Institute on Minority Health and Health Disparities; National Research Foundation of Korea; Lundbeckfonden; Else Kröner-Fresenius-Stiftung; Stanley Medical Research Institute; Department of Health, Government of Western Australia; Huazhong University of Science and Technology; Accare; Hjerteforeningen; Ministero della Salute; Fundación Marqués de Valdecilla; Amsterdam University Medical Centers; Fonds Wetenschappelijk Onderzoek; Oulun Yliopisto; Universität Wien; Nederlandse Zuivel Organisatie; Fondation ARC pour la Recherche sur le Cancer; Ministerie van Volksgezondheid, Welzijn en Sport; Nierstichting; KfH-Stiftung Präventivmedizin; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Landelijke Stichting voor Blinden en Slechtzienden; Turun Yliopistollinen Keskussairaala; Capital Medical University; Deutsche Krebshilfe; Office of the First Minister and Deputy First Minister; Academia Sinica; Vrije Universiteit Amsterdam; Sydäntutkimussäätiö; Universitair Medisch Centrum Groningen; Universiteit van Amsterdam; Sundhed og Sygdom, Det Frie Forskningsråd; University of Notre Dame Australia; China-Japan Friendship Hospital; TrygFonden; Edith Cowan University; McGovern Medical School; Universitätsklinikum Regensburg; Danmarks Grundforskningsfond; Rijksuniversiteit Groningen; National Institute of Nursing Research; National Institute for Nutrition and Health; Universiteit Leiden; Queen Mary University of London; Cotswold Foundation; Norges Forskningsråd; Science Foundation Ireland; United Kingdom Clinical Research Collaboration; Stockholms Läns Landsting; GlaxoSmithKline; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Ministero dell’Istruzione, dell’Università e della Ricerca; Curtin University of Technology; March of Dimes Foundation; Eesti Teadusagentuur; British Heart Foundation; Centre for Ageing Research and Development in Ireland; Universiteit Utrecht; Norges Teknisk-Naturvitenskapelige Universitet; Scottish Government; National Center for Chronic Disease Prevention and Health Promotion; Council of Scientific and Industrial Research, India; Cancer Australia; Samsung; Prostate Cancer Foundation of Australia; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Rosetrees Trust; Massachusetts General Hospital; Oak Foundation; Scottish Funding Council; Movember Foundation; Imperial College London; National Research Foundation Singapore; National Research Foundation; Austrian Science Fund; National Institute for Health and Care Research; Skånes universitetssjukhus; National Institutes of Health; National University of Singapore; Cancer Research UK; University of Notre Dame; Kompetenznetz Vorhofflimmern; Oogfonds; Daiichi-Sankyo; Steno Diabetes Center Copenhagen; Albert-Ludwigs-Universität Freiburg; Stiftelsen för Strategisk Forskning; Jawaharlal Nehru University; Moonshot Research and Development Program; National Institute of Biomedical Innovation; Public Health Agency; Department for the Economy; European Federation of Pharmaceutical Industries and Associations; Region Hovedstaden; Cancer Research Institute; U.S. Department of Veterans Affairs; NorthShore University HealthSystem; Medical Research Council Canada; University of Texas Health Science Center at Houston; European Regional Development Fund; Karolinska Institutet; Vlaamse regering; Broad Institute; Australian Government; ZonMw; Foundation for Cardiovascular Research; Alliance de recherche numérique du Canada; Wellcome Trust; Finska Läkaresällskapet; Kela; Economic and Social Research Council; National Natural Science Foundation of China; Koninklijke Nederlandse Akademie van Wetenschappen; Pancreatic Cancer UK; Raine Medical Research Foundation; Signe ja Ane Gyllenbergin Säätiö; Japan Agency for Medical Research and Development; Université de Lausanne; National Science Foundation; Korea National Institute of Health; Center for Translational Molecular Medicine; National Center for Global Health and Medicine; Murdoch University; Children's Hospital of Philadelphia; Ministry of Education, Culture, Sports, Science and Technology; Helsingin ja Uudenmaan Sairaanhoitopiiri; Genome Canada; National Medical Research Council; Suomen Kulttuurirahasto; Government of Canada; Strategiske Forskningsråd; Bristol-Myers Squibb; Helmholtz Zentrum München; Helsingin Yliopisto; Prostate Cancer Canada; Victor Chang Cardiac Research Institute; Queen's University; American Diabetes Association; University of California, San Francisco; Government of Western Australia; Women and Infants Research Foundation; National Institute of Neurological Disorders and Stroke; Paavo Nurmen Säätiö; Cancer Council Queensland; Ovarian Cancer Research Fund; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Fondation de France; University of Pennsylvania; Bundesministerium für Bildung und Forschung; European Science Foundation; Velux Stiftung; Stiftelsen Kristian Gerhard Jebsen; Queen's University Belfast; Deutsche Herzstiftung; Translational Genomics Research Institute; Atlantic Philanthropies; Leids Universitair Medisch Centrum; Carolina Population Center, University of North Carolina at Chapel Hill; Sanofi; Deutsches Zentrum für Herz-Kreislaufforschung; Departament d'Universitats, Recerca i Societat de la Informació; U.S. Department of Health and Human Services; Pfizer; Mitsubishi Tanabe Pharma Corporation; Agency for Science, Technology and Research; Knut och Alice Wallenbergs Stiftelse; National Heart, Lung, and Blood Institute; AstraZeneca; National University Health System; National Institute on Drug Abuse; National Cancer Research Institute; Diabetesliitto; Amgen; National Science Council; Breast Cancer Research Foundation; Boettcher Foundation; Foundation for the National Institutes of Health","keywords":"Genetics; Biology; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002354923,0.0001192077,0.000205955,0.00003950199,0.0001967739,0.000004690106,0.0002155621,0.0005664841,0.0001262946],"category_scores_gemma":[0.00006976247,0.0001051873,0.0000606112,0.0001447285,0.00004597938,0.000001001777,0.0001325863,0.0007207044,0.000001616643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003149653,"about_ca_system_score_gemma":0.0000635051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002761795,"about_ca_topic_score_gemma":0.0001085487,"domain_scores_codex":[0.9989295,0.0002478989,0.000203632,0.0002497382,0.0001575742,0.0002116734],"domain_scores_gemma":[0.9993546,0.00002262646,0.000211869,0.0002709393,0.00009956775,0.00004039239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002375925,0.0008262993,0.4530966,0.00003027551,0.0009711122,0.00003706281,0.0002698656,0.00327598,0.4216136,0.0006134103,0.1182668,0.0007614082],"study_design_scores_gemma":[0.001150488,0.0009611254,0.9728289,0.000009241976,0.00006569539,0.00002171102,0.00009825402,0.0001414838,0.003729476,0.0006267332,0.02010491,0.0002619557],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971978,0.001164323,0.00003701409,0.0004470204,0.0001319843,0.00014519,0.0001164642,0.00001087285,0.0007493141],"genre_scores_gemma":[0.9968032,0.000009192903,0.0004234063,0.0006711557,0.00005642871,0.0000256627,0.0007843178,0.00001882518,0.001207776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5197324,"threshold_uncertainty_score":0.4369244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006661596522727594,"score_gpt":0.2506274951760112,"score_spread":0.2439658986532836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}