{"id":"W4304698823","doi":"10.1038/s41586-022-05275-y","title":"A saturated map of common genetic variants associated with human height","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":895,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Dalhousie University; Montreal Heart Institute; Université de Montréal; Université Laval","funders":"Daiichi Sankyo Europe; European Social Fund; Core Research for Evolutional Science and Technology; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Biosense Webster; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Environmental Health Sciences; Fogarty International Center; National Institute of General Medical Sciences; National Cancer Institute; National Eye Institute; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; School of Public Health, Imperial College London; Tongji Medical College, Huazhong University of Science and Technology; Biomedical Research Council; National Key Research and Development Program of China; Health and Social Care Research and Development Division; Japan Society for the Promotion of Science; Cancer Council Tasmania; Cancer Council Victoria; Medical Research Council; Canadian Cancer Society Research Institute; National Health and Medical Research Council; Canadian Institutes of Health Research; Weill Cornell Medicine - Qatar; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Mental Health; Helsinki Institute of Life Science, Helsingin Yliopisto; Forsknings- og Innovationsstyrelsen; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Stanley Center for Psychiatric Research, Broad Institute; Perelman School of Medicine, University of Pennsylvania; Weill Cornell Medical College; Centers for Disease Control and Prevention; Turun Yliopistosäätiö; Ministry of Cultural Affairs; Avera Institute for Human Genetics; Diabetesforeningen; Heinz Nixdorf Stiftung; National Human Genome Research Institute; MRC-PHE Centre for Environment and Health; Ministerie van Economische Zaken, Landbouw en Innovatie; Provincia autonoma di Bolzano - Alto Adige; Freistaat Sachsen; Xarxa de Bancs de Tumors de Catalunya; Business Finland; Diabetestutkimussäätiö; Wageningen University and Research; H. Lundbeck A/S; Hjartavernd; Danish Agency for Science and Higher Education; Institut de Cardiologie de Montréal; Fondation Institut de Cardiologie de Montréal; Takeda Pharmaceutical Company; Medizinische Universität Wien; Fondation du cancer du sein du Québec; Servier; University of North Carolina at Chapel Hill; European Commission; Tays; Swedish Cancer Foundation; Stichting Blindenhulp; Medizinische Universität Graz; Egmont Fonden; Rush University; Alexandria University; Consejo Nacional de Ciencia y Tecnología; Novo Nordisk Fonden; University of Bristol; Safe Work Australia; Wake Forest School of Medicine; Karl-Franzens-Universität Graz; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Salud Carlos III; Otsuka Pharmaceutical; School of Medicine, Boston University; Yrjö Jahnssonin Säätiö; Ministeriet Sundhed Forebyggelse; Novo Nordisk; Institut National Du Cancer; Chinese Society of Clinical Oncology; Helsefonden; Lastentautien Tutkimussäätiö; Fundación IMSS; Augustinus Fonden; Astellas Pharma; Instituto Mexicano del Seguro Social; Deutsche Forschungsgemeinschaft; Taichung Veterans General Hospital; Helse Midt-Norge; Diabetes UK; University College London; Tongji University; Faculty of Medicine and Health, University of Sydney; Oesterreichische Nationalbank; Regione Campania; KU Leuven; Juho Vainion Säätiö; Hjärt-Lungfonden; Barts and The London School of Medicine and Dentistry; Emil Aaltosen Säätiö; National Institute on Minority Health and Health Disparities; National Research Foundation of Korea; Lundbeckfonden; Else Kröner-Fresenius-Stiftung; Stanley Medical Research Institute; Department of Health, Government of Western Australia; Huazhong University of Science and Technology; Accare; Hjerteforeningen; Ministero della Salute; Fundación Marqués de Valdecilla; Amsterdam University Medical Centers; Fonds Wetenschappelijk Onderzoek; Oulun Yliopisto; Universität Wien; Nederlandse Zuivel Organisatie; Fondation ARC pour la Recherche sur le Cancer; Ministerie van Volksgezondheid, Welzijn en Sport; Nierstichting; KfH-Stiftung Präventivmedizin; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Landelijke Stichting voor Blinden en Slechtzienden; Turun Yliopistollinen Keskussairaala; Capital Medical University; Deutsche Krebshilfe; Office of the First Minister and Deputy First Minister; Academia Sinica; Vrije Universiteit Amsterdam; Sydäntutkimussäätiö; Universitair Medisch Centrum Groningen; Universiteit van Amsterdam; Sundhed og Sygdom, Det Frie Forskningsråd; University of Notre Dame Australia; China-Japan Friendship Hospital; TrygFonden; Edith Cowan University; McGovern Medical School; Universitätsklinikum Regensburg; Danmarks Grundforskningsfond; Rijksuniversiteit Groningen; National Institute of Nursing Research; National Institute for Nutrition and Health; Universiteit Leiden; Queen Mary University of London; Cotswold Foundation; Norges Forskningsråd; Science Foundation Ireland; United Kingdom Clinical Research Collaboration; Stockholms Läns Landsting; GlaxoSmithKline; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Ministero dell’Istruzione, dell’Università e della Ricerca; Curtin University of Technology; March of Dimes Foundation; Eesti Teadusagentuur; British Heart Foundation; Centre for Ageing Research and Development in Ireland; Universiteit Utrecht; Norges Teknisk-Naturvitenskapelige Universitet; Scottish Government; National Center for Chronic Disease Prevention and Health Promotion; Council of Scientific and Industrial Research, India; Cancer Australia; Samsung; Prostate Cancer Foundation of Australia; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Rosetrees Trust; Massachusetts General Hospital; Oak Foundation; Scottish Funding Council; Movember Foundation; Imperial College London; National Research Foundation Singapore; National Research Foundation; Austrian Science Fund; National Institute for Health and Care Research; Skånes universitetssjukhus; National Institutes of Health; National University of Singapore; Cancer Research UK; University of Notre Dame; Kompetenznetz Vorhofflimmern; Oogfonds; Daiichi-Sankyo; Steno Diabetes Center Copenhagen; Albert-Ludwigs-Universität Freiburg; Stiftelsen för Strategisk Forskning; Jawaharlal Nehru University; Moonshot Research and Development Program; National Institute of Biomedical Innovation; Public Health Agency; Department for the Economy; European Federation of Pharmaceutical Industries and Associations; Region Hovedstaden; Cancer Research Institute; U.S. Department of Veterans Affairs; NorthShore University HealthSystem; Medical Research Council Canada; University of Texas Health Science Center at Houston; European Regional Development Fund; Karolinska Institutet; Vlaamse regering; Broad Institute; Australian Government; ZonMw; Foundation for Cardiovascular Research; Alliance de recherche numérique du Canada; Wellcome Trust; Finska Läkaresällskapet; Kela; Economic and Social Research Council; National Natural Science Foundation of China; Koninklijke Nederlandse Akademie van Wetenschappen; Pancreatic Cancer UK; Raine Medical Research Foundation; Signe ja Ane Gyllenbergin Säätiö; Japan Agency for Medical Research and Development; Université de Lausanne; National Science Foundation; Korea National Institute of Health; Center for Translational Molecular Medicine; National Center for Global Health and Medicine; Murdoch University; Children's Hospital of Philadelphia; Ministry of Education, Culture, Sports, Science and Technology; Helsingin ja Uudenmaan Sairaanhoitopiiri; Genome Canada; National Medical Research Council; Suomen Kulttuurirahasto; Government of Canada; Strategiske Forskningsråd; Bristol-Myers Squibb; Helmholtz Zentrum München; Helsingin Yliopisto; Prostate Cancer Canada; Victor Chang Cardiac Research Institute; Queen's University; American Diabetes Association; University of California, San Francisco; Government of Western Australia; Women and Infants Research Foundation; National Institute of Neurological Disorders and Stroke; Paavo Nurmen Säätiö; Cancer Council Queensland; Ovarian Cancer Research Fund; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Fondation de France; University of Pennsylvania; Bundesministerium für Bildung und Forschung; European Science Foundation; Velux Stiftung; Stiftelsen Kristian Gerhard Jebsen; Queen's University Belfast; Deutsche Herzstiftung; Translational Genomics Research Institute; Atlantic Philanthropies; Leids Universitair Medisch Centrum; Carolina Population Center, University of North Carolina at Chapel Hill; Sanofi; Deutsches Zentrum für Herz-Kreislaufforschung; Departament d'Universitats, Recerca i Societat de la Informació; U.S. Department of Health and Human Services; Pfizer; Mitsubishi Tanabe Pharma Corporation; Agency for Science, Technology and Research; Knut och Alice Wallenbergs Stiftelse; National Heart, Lung, and Blood Institute; AstraZeneca; National University Health System; National Institute on Drug Abuse; National Cancer Research Institute; Diabetesliitto; Amgen; National Science Council; Breast Cancer Research Foundation; Boettcher Foundation; Foundation for the National Institutes of Health","keywords":"Genetics; Biology; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005972036,0.00030657,0.0006835199,0.001937752,0.0004822187,0.0007917975,0.0004382785,0.0003245624,0.005843253],"category_scores_gemma":[0.00195219,0.0002927026,0.0005837019,0.002115213,0.0005159702,0.0003288801,0.00119,0.0004631076,0.0007156125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002412726,"about_ca_system_score_gemma":0.0004316402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004865743,"about_ca_topic_score_gemma":0.003477223,"domain_scores_codex":[0.9994715,0.0001122653,0.00002025497,0.0002234419,0.0000927591,0.0000798048],"domain_scores_gemma":[0.9981565,0.001091833,0.0002059942,0.0001683998,0.0001822017,0.000195133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003752797,0.0002339425,0.6489967,0.0009059906,0.002223731,0.003412676,0.001586939,0.01194951,0.2115719,0.004897998,0.002957073,0.1075106],"study_design_scores_gemma":[0.00005196622,0.0001946953,0.9829966,0.00005361786,0.0002468956,0.0008792665,0.0002245079,0.004385242,0.002453886,0.005174204,0.003307363,0.00003180154],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808285,0.002760485,0.01039354,0.0002721819,0.00001471948,0.00002496247,0.003188,0.0001599149,0.0023578],"genre_scores_gemma":[0.9951537,0.0003495175,0.001991647,0.00007004223,0.00001794235,0.0000111118,0.001959614,0.00001087003,0.0004356313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005843253,"threshold_uncertainty_score":0.01954764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006661596522727594,"score_gpt":0.2506274951760112,"score_spread":0.2439658986532836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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