{"id":"W4304758004","doi":"10.1371/journal.pone.0273520","title":"Mitochondrial fitness and cancer risk","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; University Health Network; Mount Sinai Hospital; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health","keywords":"Biology; Transcriptome; Gene signature; Phenotype; Downregulation and upregulation; Cancer; Bioinformatics; Gene; Disease; Mitochondrion; Cancer research; Gene expression; Internal medicine; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003445927,0.00004625098,0.00005634702,0.00001219748,0.0001576073,0.000009157764,0.00007269747,0.00002216038,0.0002371199],"category_scores_gemma":[0.00001305077,0.00004834943,0.00001703251,0.00003938706,0.00002451049,0.000001017741,0.00008437282,0.00006283914,0.000001904595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001077909,"about_ca_system_score_gemma":0.0000334183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008160384,"about_ca_topic_score_gemma":0.00002307997,"domain_scores_codex":[0.999567,0.00003113659,0.00005916514,0.0001657941,0.00009476441,0.0000820839],"domain_scores_gemma":[0.9997485,0.000002902324,0.00003476493,0.0001599531,0.00002444782,0.00002941711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006450112,0.0002584666,0.008315888,0.00001010529,0.0001162143,4.621679e-7,0.00004674137,0.00006776727,0.9853387,0.00005022335,0.002385871,0.003345094],"study_design_scores_gemma":[0.002386917,0.0006482445,0.02239901,0.00002212448,0.0003350167,0.000005587985,0.000291212,0.0007206349,0.7573947,0.0003617682,0.2148241,0.0006106982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961309,0.002867698,0.00006688685,0.0002415332,0.00007107441,0.0001019957,0.0001231878,0.000005842985,0.0003908641],"genre_scores_gemma":[0.9942521,0.001567242,0.0004232737,0.0001427159,0.0003052933,0.0003198351,0.00004730097,0.00001076972,0.002931473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2279439,"threshold_uncertainty_score":0.2596297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02271631663168796,"score_gpt":0.2369363499042669,"score_spread":0.2142200332725789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}