{"id":"W4304775474","doi":"10.1101/2022.10.12.511840","title":"Molecular evidence of widespread benzimidazole drug resistance in <i>Ancylostoma caninum</i> from domestic dogs throughout the USA and discovery of a novel isotype-1 β-tubulin benzimidazole resistance mutation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Helminth infection and control","field":"Veterinary","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Ancylostoma caninum; Benzimidazole; Biology; Isotype; Drug resistance; Genetics; Virology; Immunology; Antibody; Helminths; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001072551,0.0006124669,0.0009669377,0.0002755571,0.0001785376,0.0001442729,0.0008146128,0.0003081068,0.00006647034],"category_scores_gemma":[0.001002959,0.0006057794,0.0001998985,0.00092385,0.0003377859,0.0004532904,0.0006832971,0.001009868,0.000006584102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003945163,"about_ca_system_score_gemma":0.0008234224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002758825,"about_ca_topic_score_gemma":0.002019559,"domain_scores_codex":[0.9957775,0.0005369622,0.001276384,0.001160972,0.0007581048,0.0004900137],"domain_scores_gemma":[0.995612,0.0009105542,0.001217839,0.001684252,0.0004489325,0.0001264261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001784936,0.000443898,0.02345574,0.001500207,0.0002740562,0.000340027,0.0004417283,0.0009117179,0.96702,0.003647993,0.0001772186,0.000002443154],"study_design_scores_gemma":[0.005682543,0.0003609216,0.6439114,0.01025572,0.000956112,5.742201e-7,0.0001502767,0.002112299,0.3304982,0.000212453,0.003055566,0.002803994],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835732,0.01091025,0.001870333,0.0006384741,0.0006625589,0.001183561,0.0010243,0.00008762442,0.00004970046],"genre_scores_gemma":[0.996986,0.0003891972,0.001713808,0.0002080122,0.00008780032,0.000477535,0.000001643623,0.0001121791,0.0000237856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6365219,"threshold_uncertainty_score":0.9996393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397776615118921,"score_gpt":0.285706413791195,"score_spread":0.2617286476400058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}