{"id":"W4304775474","doi":"10.1101/2022.10.12.511840","title":"Molecular evidence of widespread benzimidazole drug resistance in <i>Ancylostoma caninum</i> from domestic dogs throughout the USA and discovery of a novel isotype-1 β-tubulin benzimidazole resistance mutation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Helminth infection and control","field":"Veterinary","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Ancylostoma caninum; Benzimidazole; Biology; Isotype; Drug resistance; Genetics; Virology; Immunology; Antibody; Helminths; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006876484,0.0001590239,0.0001452033,0.0004586337,0.0002389617,0.0002058093,0.0001904456,0.0003039281,0.0009224034],"category_scores_gemma":[0.000187622,0.00008439684,0.0002001424,0.0003153608,0.0001660641,0.00007885645,0.0001388342,0.0002448469,0.0001357937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002866911,"about_ca_system_score_gemma":0.0001336538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006729061,"about_ca_topic_score_gemma":0.008908925,"domain_scores_codex":[0.9999081,0.000008378963,0.000009757781,0.00002862681,0.00002608032,0.00001907662],"domain_scores_gemma":[0.9998568,0.00002366839,0.00006191866,0.000007029682,0.00002244779,0.00002823411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001828123,0.00006440965,0.06416487,0.00008286738,0.00005331332,0.002136698,0.0001636906,0.0001871915,0.928749,0.000127236,0.0002503137,0.003837541],"study_design_scores_gemma":[0.00003902368,0.0006357478,0.8041279,0.00004782591,0.0001945634,0.01377012,0.000710869,0.003162728,0.1713252,0.0001207954,0.005838862,0.00002620408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986402,0.0001176235,0.0002381152,0.00004227931,0.000006353226,0.00001091193,0.0003471148,0.00001009834,0.0005872346],"genre_scores_gemma":[0.9989743,0.00006098987,0.0003645029,0.00002683958,0.000003199706,0.00000364038,0.000393162,0.000002553951,0.0001707765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006729061,"threshold_uncertainty_score":0.01337981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397776615118921,"score_gpt":0.285706413791195,"score_spread":0.2617286476400058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}