{"id":"W4304808793","doi":"10.1101/2022.10.11.511739","title":"Therapeutic trial of anle138b in mouse models of genetic prion disease","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institutes of Health","keywords":"Astrogliosis; Disease; Biology; Phenotype; In vivo; Bioluminescence imaging; Transmissible spongiform encephalopathy; Prion protein; Medicine; Genetics; Pathology; Neuroscience; Scrapie; Luciferase; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005705095,0.0008350215,0.0008564893,0.0005665065,0.0002792258,0.0005475257,0.0005944198,0.001272507,0.002573902],"category_scores_gemma":[0.0002198705,0.0001839078,0.0003547771,0.0002343605,0.0004670245,0.0003560313,0.0002173726,0.001718564,0.0004691974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004703157,"about_ca_system_score_gemma":0.0003979524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006872372,"about_ca_topic_score_gemma":0.001225967,"domain_scores_codex":[0.9997844,0.0000423387,0.00001494558,0.00004104671,0.00004718891,0.00007010692],"domain_scores_gemma":[0.9996709,0.00003526653,0.00006215768,0.00003388032,0.00004074263,0.0001570706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01225469,0.005858134,0.0004215897,0.0002466227,0.0001225849,0.0002964755,0.00005537321,0.0007104974,0.9610019,0.0006073912,0.001219972,0.01720458],"study_design_scores_gemma":[0.007009392,0.09277709,0.004275657,0.00008243623,0.0002060207,0.0006253424,0.00009591723,0.002981582,0.8789749,0.0006311856,0.01229359,0.00004687677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926442,0.002088056,0.001449861,0.0004415289,0.0001828554,0.000279492,0.001037892,0.0002986884,0.001577442],"genre_scores_gemma":[0.9853137,0.001584424,0.002645074,0.0003188932,0.00007152493,0.0006178411,0.001697987,0.00005750018,0.007693084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002573902,"threshold_uncertainty_score":0.008610606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01730918695023881,"score_gpt":0.2403239124985311,"score_spread":0.2230147255482923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}