{"id":"W4304889921","doi":"10.1007/978-1-0716-2617-7_18","title":"Machine Learning and Hybrid Methods for Metabolic Pathway Modeling","year":2022,"lang":"en","type":"review","venue":"Methods in molecular biology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"","keywords":"Computer science; Metabolic network; Machine learning; Artificial intelligence; Metabolomics; Flux (metallurgy); Bioinformatics; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0041334,0.0005700488,0.001600603,0.0003562493,0.0001204055,0.00002188683,0.0003322487,0.0004670582,0.00002133806],"category_scores_gemma":[0.00161181,0.0005222301,0.0004899781,0.0002765819,0.00007259712,0.000002281757,0.0004421903,0.0006901503,5.961572e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002795043,"about_ca_system_score_gemma":0.0001160092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000261272,"about_ca_topic_score_gemma":0.000001362145,"domain_scores_codex":[0.9940897,0.003482171,0.0007111072,0.001163482,0.00005025332,0.0005033521],"domain_scores_gemma":[0.9990556,0.0001039092,0.0002494329,0.0004675867,0.0000399563,0.00008353149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001187811,0.00002035604,5.660635e-7,0.0008691467,0.0001528349,0.000001940429,0.000006442214,0.0001869817,0.1692253,0.0003615679,0.000002373892,0.8291606],"study_design_scores_gemma":[0.0002509654,0.0001674067,1.776771e-8,0.0001099134,0.0002707712,0.0001507946,0.000005425436,0.002098604,0.01576532,0.0003747525,0.9802751,0.0005309407],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000005001493,0.5104936,0.4886067,0.000005395048,0.0003922659,0.00041818,0.00003557559,0.00001744689,0.0000259203],"genre_scores_gemma":[6.961976e-7,0.5333048,0.465455,0.00002459285,0.0001531701,0.0003008865,0.0005743055,0.00007223235,0.0001143855],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9802727,"threshold_uncertainty_score":0.9997229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04179380506235907,"score_gpt":0.4193644341780352,"score_spread":0.3775706291156761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}