{"id":"W4304891537","doi":"10.1002/jex2.58","title":"Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS‐CoV‐2 spike protein","year":2022,"lang":"en","type":"article","venue":"Journal of Extracellular Biology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; University of Toronto; Lunenfeld-Tanenbaum Research Institute; McGill University Health Centre; University of Calgary","funders":"","keywords":"Green fluorescent protein; Cell biology; Biology; Microvesicles; HEK 293 cells; CD81; Proteomics; Quantitative proteomics; Exosome; Transmembrane protein; Basigin; Virology; Virus; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001553812,0.0003623716,0.0006486345,0.0002485221,0.0001632277,0.00002226232,0.0006624628,0.0002728092,0.0000475575],"category_scores_gemma":[0.0006304664,0.0003364848,0.0002997853,0.0002413381,0.0003391572,0.00001886122,0.0005710943,0.0005044955,0.000002703769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004893469,"about_ca_system_score_gemma":0.0002131863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001144535,"about_ca_topic_score_gemma":0.000003475351,"domain_scores_codex":[0.9969311,0.0008433989,0.0009191534,0.000554447,0.000282038,0.0004698051],"domain_scores_gemma":[0.9980447,0.00008760669,0.0008842596,0.0005044793,0.0002488025,0.0002302119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001884483,0.0005305865,0.00101072,0.00007117964,0.0001627427,0.00009223723,0.000153379,0.0003339223,0.9932958,0.001129198,0.0001469993,0.001188739],"study_design_scores_gemma":[0.001115163,0.004811749,0.0005320113,0.00005831398,0.00005177766,0.0002121991,0.000246918,0.0001741588,0.9872019,0.0006273007,0.004582,0.0003864937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465964,0.01406104,0.03783124,0.0002361958,0.0002141196,0.0009066387,0.0001178399,0.00001130782,0.00002520679],"genre_scores_gemma":[0.9720608,0.0001473115,0.02729382,0.00004902919,0.0001620275,0.00007886875,0.00003456102,0.00004829168,0.0001252652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02546442,"threshold_uncertainty_score":0.9999087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02720024013843838,"score_gpt":0.2861496789926047,"score_spread":0.2589494388541663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}