{"id":"W4304975395","doi":"10.26508/lsa.202201496","title":"Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus","year":2022,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Rheumatology Research Foundation","keywords":"Autoantibody; Systemic lupus erythematosus; Immunology; Autoimmunity; Guanosine; Medicine; Ribonucleoprotein; RNA; Biology; Antibody; Internal medicine; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000515084,0.0003214522,0.0003371739,0.0002907912,0.0001495056,0.0004434262,0.0003380553,0.0006451624,0.002913442],"category_scores_gemma":[0.0002713957,0.00007058655,0.0002172,0.0001752155,0.0003388491,0.0005278682,0.0003564121,0.0009230342,0.0004576892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000191285,"about_ca_system_score_gemma":0.000283082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001314345,"about_ca_topic_score_gemma":0.0004177084,"domain_scores_codex":[0.9998957,0.00003609472,0.000007753622,0.00001470254,0.00001844716,0.00002732517],"domain_scores_gemma":[0.9998863,0.00002527828,0.00002864227,0.000009226957,0.00001348243,0.00003714367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003542861,0.001889018,0.002829844,0.00135531,0.0001309636,0.001656349,0.0002174807,0.0009415514,0.2147807,0.01121708,0.01083974,0.7505991],"study_design_scores_gemma":[0.006787873,0.03812671,0.02975362,0.00191298,0.000766133,0.01531734,0.0008740364,0.00593217,0.1713823,0.0394598,0.6895241,0.0001628397],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.371579,0.5512155,0.0183775,0.02425722,0.001236834,0.0003420327,0.0004719854,0.0007069964,0.03181301],"genre_scores_gemma":[0.7624191,0.2119747,0.008922154,0.00573768,0.001272446,0.0002885209,0.0005290006,0.00005531344,0.008801123],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002913442,"threshold_uncertainty_score":0.009746432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140849480292692,"score_gpt":0.2689380885731256,"score_spread":0.2575295937701986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}