{"id":"W4304976247","doi":"10.1038/s41467-022-33803-x","title":"Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Mechanobiology Institute, Singapore; Fondation pour la Recherche Médicale; Instituto Tecnológico de Costa Rica; Universiteit Gent; Centre National de la Recherche Scientifique; Université Sorbonne Paris Cité; Ligue Contre le Cancer; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Institut National de la Santé et de la Recherche Médicale; European Commission; Infrastructures en Biologie Santé et Agronomie","keywords":"Cell biology; Integrin; Optineurin; Ubiquitin ligase; Focal adhesion; Cell adhesion; Mechanotransduction; Cell migration; Biology; RAC1; Extracellular matrix; Paxillin; Chemistry; Ubiquitin; Cell; Signal transduction; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003466246,0.0001402442,0.0001232737,0.0001371618,0.0004896421,0.00004991598,0.0004877515,0.0002538666,0.00007669083],"category_scores_gemma":[0.000161454,0.0001522064,0.00006220544,0.0002018971,0.00001350763,0.00001091799,0.0008017911,0.0008934062,0.00001273397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005918544,"about_ca_system_score_gemma":0.00004642455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002701318,"about_ca_topic_score_gemma":0.0002404379,"domain_scores_codex":[0.9988652,0.0002289867,0.0002361503,0.0003325442,0.0001799404,0.0001572065],"domain_scores_gemma":[0.9986792,0.00005169906,0.00008561467,0.0009090175,0.0001469246,0.0001275287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001255026,0.0001487511,0.00005147849,0.000003529686,0.0000147699,3.397375e-7,0.0001660463,0.0003080643,0.9959612,0.0004094369,0.001591762,0.001219125],"study_design_scores_gemma":[0.001315941,0.0009670695,0.001214767,0.00001690638,0.00005086743,0.00002072842,0.0004238488,0.002191077,0.4223486,0.00009145294,0.5709608,0.000397913],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711773,0.0009196798,0.01626981,0.00898434,0.001012337,0.0009540001,0.0002161057,0.00004312114,0.0004232468],"genre_scores_gemma":[0.9949893,0.0002399482,0.001804137,0.001186631,0.0001037125,0.0001976793,0.001152691,0.00002538126,0.0003004783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5736126,"threshold_uncertainty_score":0.6206796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009601103642685002,"score_gpt":0.256308240212579,"score_spread":0.246707136569894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}