{"id":"W4304976247","doi":"10.1038/s41467-022-33803-x","title":"Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Mechanobiology Institute, Singapore; Fondation pour la Recherche Médicale; Instituto Tecnológico de Costa Rica; Universiteit Gent; Centre National de la Recherche Scientifique; Université Sorbonne Paris Cité; Ligue Contre le Cancer; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Institut National de la Santé et de la Recherche Médicale; European Commission; Infrastructures en Biologie Santé et Agronomie","keywords":"Cell biology; Integrin; Optineurin; Ubiquitin ligase; Focal adhesion; Cell adhesion; Mechanotransduction; Cell migration; Biology; RAC1; Extracellular matrix; Paxillin; Chemistry; Ubiquitin; Cell; Signal transduction; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211121,0.0002257641,0.0001146577,0.00008937328,0.0001428532,0.0002678179,0.0001910431,0.0002123505,0.001121609],"category_scores_gemma":[0.00009700841,0.0001073852,0.0001458693,0.00007716163,0.0002269921,0.0001800062,0.0002253725,0.0002561007,0.0001878517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003273483,"about_ca_system_score_gemma":0.0001572048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003159266,"about_ca_topic_score_gemma":0.0007790776,"domain_scores_codex":[0.9999045,0.00001480346,0.000009230778,0.00002640825,0.00002277795,0.00002232363],"domain_scores_gemma":[0.9999137,0.00001274773,0.00003870608,0.0000102335,0.00000632911,0.00001826461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009687344,0.00002101663,0.0001667178,0.00002209184,0.000002756798,0.00002418598,0.000004554377,0.00006334687,0.9989253,0.00009595325,0.00001850206,0.0005586633],"study_design_scores_gemma":[0.000006250802,0.0000499421,0.004789954,0.000002466032,0.000002954408,0.0001005677,0.000006827373,0.000891832,0.9933094,0.00002472349,0.0008124626,0.000002542638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972522,0.0007216027,0.001134879,0.00006967712,0.00001320748,0.000007096231,0.0001165581,0.00001689498,0.0006678885],"genre_scores_gemma":[0.9973063,0.0003423442,0.0008527293,0.00003390847,0.000004031924,0.00001092856,0.0001619901,0.00001128392,0.001276364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121609,"threshold_uncertainty_score":0.003752172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009601103642685002,"score_gpt":0.256308240212579,"score_spread":0.246707136569894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}