{"id":"W4305042192","doi":"10.1101/2022.10.12.22280972","title":"Potential protective link between type I diabetes and Parkinson’s disease risk and progression","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Parkinson's UK; Parkinson Canada; National Institute for Health and Care Research; Barts Charity; Consortium canadien en neurodégénérescence associée au vieillissement; Killam Trusts; McGill University; Biogen; Canada First Research Excellence Fund; AstraZeneca; Michael J. Fox Foundation for Parkinson's Research","keywords":"Mendelian randomization; Parkinson's disease; Disease; Linkage disequilibrium; Genetic association; Diabetes mellitus; Epidemiology; Medicine; Internal medicine; Type 2 diabetes; Bioinformatics; Genetics; Oncology; Biology; Single-nucleotide polymorphism; Gene; Genotype; Endocrinology; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00160612,0.0004131375,0.0005908464,0.000444154,0.0002187093,0.0007091759,0.0003291725,0.0003588247,0.006723396],"category_scores_gemma":[0.004346664,0.0001397959,0.0006474087,0.000573507,0.0002945668,0.0001917234,0.0003100345,0.0004823554,0.000500138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001906032,"about_ca_system_score_gemma":0.0004444853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008111282,"about_ca_topic_score_gemma":0.0006406671,"domain_scores_codex":[0.9991692,0.0004688653,0.00003789084,0.0001675589,0.00009819256,0.00005830942],"domain_scores_gemma":[0.9981154,0.001001173,0.0004751127,0.0001695359,0.00009933956,0.000139484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008923294,0.0005695507,0.7436172,0.0009785757,0.0035254,0.001758392,0.0003890933,0.002688373,0.07066838,0.007940887,0.01196329,0.1469776],"study_design_scores_gemma":[0.0006443663,0.001162406,0.9326277,0.0002423,0.001915427,0.002470519,0.0002718615,0.008287528,0.01669387,0.02245636,0.01317977,0.00004788838],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566647,0.008930677,0.0188987,0.004142968,0.0003998934,0.00006166226,0.00327391,0.0005533925,0.00707401],"genre_scores_gemma":[0.9846841,0.001891541,0.008958384,0.0005964614,0.0001778393,0.00005724547,0.001216937,0.00007526303,0.002342358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006723396,"threshold_uncertainty_score":0.02249205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600204776619874,"score_gpt":0.2801984250780093,"score_spread":0.2641963773118106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}