{"id":"W4305070936","doi":"10.1038/s41419-022-05315-5","title":"c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance","year":2022,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"University of Toronto; Canadian Institutes of Health Research; Sun Yat-sen University; National Natural Science Foundation of China; Government of Canada","keywords":"Acute megakaryoblastic leukemia; Cancer research; Downregulation and upregulation; Biology; Gene knockdown; Myeloid leukemia; Cell growth; Thrombopoietin; Leukemia; PI3K/AKT/mTOR pathway; Apoptosis; Signal transduction; Haematopoiesis; Cell biology; Immunology; Stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007999191,0.0002148732,0.000128835,0.0002125604,0.0001206567,0.0002562538,0.00009736419,0.0001967936,0.0006309613],"category_scores_gemma":[0.00008361859,0.00006630977,0.0001029212,0.0001119352,0.0002341932,0.000149124,0.00015318,0.0004376324,0.0001669131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002531701,"about_ca_system_score_gemma":0.0001236498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001957678,"about_ca_topic_score_gemma":0.0002694953,"domain_scores_codex":[0.9998943,0.00001732545,0.000007721142,0.00002617435,0.00003293784,0.00002162676],"domain_scores_gemma":[0.9999393,0.000007304748,0.00002552814,0.000004683294,0.000006934925,0.00001623056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002707106,0.00003473616,0.002221165,0.00004330461,0.0000071196,0.0003278002,0.00001538487,0.0001047575,0.9926641,0.0001836598,0.0001357324,0.003991505],"study_design_scores_gemma":[0.0001145123,0.0006637532,0.05430071,0.00001494592,0.00003940016,0.005352383,0.00009197376,0.004039387,0.9262657,0.0002847543,0.008821209,0.00001122341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962946,0.001260424,0.001210702,0.0001269765,0.0000127407,0.00001547859,0.0001580377,0.00006447023,0.000856554],"genre_scores_gemma":[0.9984971,0.0003146674,0.0005105144,0.00003555405,0.000005939242,0.00001161761,0.0001114016,0.00000384551,0.0005093442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006309613,"threshold_uncertainty_score":0.002110839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595875332672788,"score_gpt":0.2905445603696919,"score_spread":0.274585807042964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}