{"id":"W4305070949","doi":"10.1161/hypertensionaha.122.19560","title":"MiR-1249 on Endothelial Extracellular Vesicles Mediates Cigarette Smoke–Induced Pulmonary Hypertension by Inhibiting HDAC10 (Histone Deacetylase 10)-NFκB (Nuclear Factor κB)-CaSR (Calcium-Sensing Receptor) Cascade","year":2022,"lang":"en","type":"article","venue":"Hypertension","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Government of Jiangsu Province; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Pulmonary hypertension; Medicine; Histone deacetylase; Calcium-sensing receptor; Pulmonary artery; Cancer research; Endocrinology; Internal medicine; Extracellular vesicle; Cell biology; Biology; Calcium; Histone; microRNA; Calcium metabolism; Biochemistry; Microvesicles","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006152617,0.0009888621,0.001387162,0.000654973,0.00191196,0.00008911081,0.0003670132,0.0004454437,0.002006851],"category_scores_gemma":[0.0006162807,0.0008655605,0.000560733,0.0007258835,0.0002584996,0.0003224459,0.0004910016,0.001780811,0.000564445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007105371,"about_ca_system_score_gemma":0.0002308877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005684991,"about_ca_topic_score_gemma":0.00000417533,"domain_scores_codex":[0.992354,0.0006714245,0.001065007,0.001763917,0.002546782,0.00159881],"domain_scores_gemma":[0.996348,0.0005897258,0.0003985545,0.001084119,0.0004400043,0.001139631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002816661,0.002016728,0.0001444277,0.00006799747,0.0002164945,0.01612962,0.0001486034,0.000009290212,0.9283366,0.00000916204,0.03648105,0.01362335],"study_design_scores_gemma":[0.0103908,0.005137136,0.003335727,0.0007716788,0.0006564091,0.01432307,0.002015571,0.01384505,0.8618453,0.00005952831,0.08565042,0.001969323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884271,0.003778602,0.000004853504,0.00406729,0.0008638362,0.001332158,0.0004091036,0.0004957697,0.0006213134],"genre_scores_gemma":[0.9913924,0.0004404993,0.0003571484,0.003678332,0.0004899862,0.00004279619,0.001197475,0.000340004,0.002061313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06649133,"threshold_uncertainty_score":0.9993874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05537824217899549,"score_gpt":0.2815510622779111,"score_spread":0.2261728200989156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}