{"id":"W4305070949","doi":"10.1161/hypertensionaha.122.19560","title":"MiR-1249 on Endothelial Extracellular Vesicles Mediates Cigarette Smoke–Induced Pulmonary Hypertension by Inhibiting HDAC10 (Histone Deacetylase 10)-NFκB (Nuclear Factor κB)-CaSR (Calcium-Sensing Receptor) Cascade","year":2022,"lang":"en","type":"article","venue":"Hypertension","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Government of Jiangsu Province; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Pulmonary hypertension; Medicine; Histone deacetylase; Calcium-sensing receptor; Pulmonary artery; Cancer research; Endocrinology; Internal medicine; Extracellular vesicle; Cell biology; Biology; Calcium; Histone; microRNA; Calcium metabolism; Biochemistry; Microvesicles","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152894,0.0003682475,0.0003102202,0.0001569496,0.0001621641,0.0002719914,0.0002184802,0.0002420779,0.001435957],"category_scores_gemma":[0.0001446735,0.0001765198,0.0004382549,0.00009282601,0.0002370182,0.0001585529,0.0001962071,0.0004141801,0.0004352178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002518914,"about_ca_system_score_gemma":0.0002294256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000378256,"about_ca_topic_score_gemma":0.0005295428,"domain_scores_codex":[0.9998237,0.0000249243,0.00001858594,0.00004901816,0.00004268917,0.00004111949],"domain_scores_gemma":[0.9999228,0.00001189023,0.00002727381,0.000008715273,0.00001068546,0.00001865743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002525304,0.00003830103,0.0003674189,0.00004648798,0.0000118439,0.00003959398,0.000009842655,0.00004195688,0.9977545,0.00008659254,0.00006442502,0.001286492],"study_design_scores_gemma":[0.00004225284,0.0003779884,0.007840569,0.00000716864,0.0000533804,0.0001906239,0.00002852502,0.001427225,0.9875886,0.00005329179,0.002384878,0.000005502671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894453,0.002473516,0.005245243,0.0001482118,0.000100694,0.0000416248,0.0004899942,0.0002100432,0.001845315],"genre_scores_gemma":[0.9942022,0.0008731806,0.001982503,0.00007989041,0.00001544836,0.00004732055,0.0006104251,0.00003067802,0.002158299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435957,"threshold_uncertainty_score":0.004803777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05537824217899549,"score_gpt":0.2815510622779111,"score_spread":0.2261728200989156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}