{"id":"W4305071862","doi":"10.1165/rcmb.2022-0021oc","title":"Antifibrotic Drug Nintedanib Inhibits CSF1R to Promote IL-4–associated Tissue Repair Macrophages","year":2022,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Nintedanib; Macrophage; Cancer research; In vivo; Idiopathic pulmonary fibrosis; Fibrosis; Inflammation; Biology; Cytokine; Pulmonary fibrosis; Immunology; In vitro; Medicine; Lung; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101704,0.0003040026,0.0002584346,0.0002209328,0.0001526032,0.0001431875,0.000156003,0.0001848152,0.001187875],"category_scores_gemma":[0.0000682684,0.0001199689,0.0002011411,0.00007459911,0.0001842277,0.000135379,0.0000938484,0.0005290386,0.0002758398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528809,"about_ca_system_score_gemma":0.0002495464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003828428,"about_ca_topic_score_gemma":0.001183194,"domain_scores_codex":[0.9999125,0.00001803111,0.000009008431,0.00001465997,0.00002085691,0.00002486748],"domain_scores_gemma":[0.9999514,0.000008935352,0.00001057384,0.000005250348,0.000008869047,0.00001500248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001788025,0.00004507386,0.00007220973,0.0000279721,0.000003828293,0.00001674434,0.000004942283,0.00004174896,0.9980962,0.00003437413,0.00005275098,0.001425349],"study_design_scores_gemma":[0.00006497847,0.0007979758,0.001863536,0.000003991704,0.000009551776,0.0001359048,0.00001163998,0.0007385847,0.9944377,0.00002636955,0.001906663,0.000003052777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925075,0.002301766,0.002469829,0.0002121345,0.00009451461,0.00005832496,0.0002725513,0.000121389,0.001962005],"genre_scores_gemma":[0.9945753,0.0009456373,0.002241033,0.00008630361,0.00001927149,0.00006460057,0.0002761694,0.00001142761,0.001780257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187875,"threshold_uncertainty_score":0.003973782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005091733484913408,"score_gpt":0.2588699661703517,"score_spread":0.2537782326854383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}